The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα

Peroxisome Proliferator Activated Receptor alpha (PPARα) drives fatty acid catabolism. Here, the authors show that in liver of autophagy deficient class 3 phosphoinositide 3-kinase mutant mice PPARα transcriptional repressors fail to degrade in lysosomes and accumulate leading to PPARα inhibition an...

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Autores principales:	Anton Iershov, Ivan Nemazanyy, Chantal Alkhoury, Muriel Girard, Esther Barth, Nicolas Cagnard, Alexandra Montagner, Dominique Chretien, Elena I. Rugarli, Herve Guillou, Mario Pende, Ganna Panasyuk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/942549d8fc9a4e9396af183cc1bf5645
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spelling	oai:doaj.org-article:942549d8fc9a4e9396af183cc1bf56452021-12-02T15:36:06ZThe class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα10.1038/s41467-019-09598-92041-1723https://doaj.org/article/942549d8fc9a4e9396af183cc1bf56452019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09598-9https://doaj.org/toc/2041-1723Peroxisome Proliferator Activated Receptor alpha (PPARα) drives fatty acid catabolism. Here, the authors show that in liver of autophagy deficient class 3 phosphoinositide 3-kinase mutant mice PPARα transcriptional repressors fail to degrade in lysosomes and accumulate leading to PPARα inhibition and blunted transcriptional responses during fasting.Anton IershovIvan NemazanyyChantal AlkhouryMuriel GirardEsther BarthNicolas CagnardAlexandra MontagnerDominique ChretienElena I. RugarliHerve GuillouMario PendeGanna PanasyukNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anton Iershov Ivan Nemazanyy Chantal Alkhoury Muriel Girard Esther Barth Nicolas Cagnard Alexandra Montagner Dominique Chretien Elena I. Rugarli Herve Guillou Mario Pende Ganna Panasyuk The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
description	Peroxisome Proliferator Activated Receptor alpha (PPARα) drives fatty acid catabolism. Here, the authors show that in liver of autophagy deficient class 3 phosphoinositide 3-kinase mutant mice PPARα transcriptional repressors fail to degrade in lysosomes and accumulate leading to PPARα inhibition and blunted transcriptional responses during fasting.
format	article
author	Anton Iershov Ivan Nemazanyy Chantal Alkhoury Muriel Girard Esther Barth Nicolas Cagnard Alexandra Montagner Dominique Chretien Elena I. Rugarli Herve Guillou Mario Pende Ganna Panasyuk
author_facet	Anton Iershov Ivan Nemazanyy Chantal Alkhoury Muriel Girard Esther Barth Nicolas Cagnard Alexandra Montagner Dominique Chretien Elena I. Rugarli Herve Guillou Mario Pende Ganna Panasyuk
author_sort	Anton Iershov
title	The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
title_short	The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
title_full	The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
title_fullStr	The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
title_full_unstemmed	The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
title_sort	class 3 pi3k coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor pparα
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/942549d8fc9a4e9396af183cc1bf5645
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The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα

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