The dental phenotype of hairless dogs with FOXI3 haploinsufficiency

Abstract Hairless dog breeds show a form of ectodermal dysplasia characterised by a lack of hair and abnormal tooth morphology. This has been attributed to a semi-dominant 7-base-pair duplication in the first exon of the forkhead box I3 gene (FOXI3) shared by all three breeds. Here, we identified th...

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Autores principales:	Kornelius Kupczik, Alexander Cagan, Silke Brauer, Martin S. Fischer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/94261aecac0f47f6ac00b8280aefedaa
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spelling	oai:doaj.org-article:94261aecac0f47f6ac00b8280aefedaa2021-12-02T15:05:53ZThe dental phenotype of hairless dogs with FOXI3 haploinsufficiency10.1038/s41598-017-05764-52045-2322https://doaj.org/article/94261aecac0f47f6ac00b8280aefedaa2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05764-5https://doaj.org/toc/2045-2322Abstract Hairless dog breeds show a form of ectodermal dysplasia characterised by a lack of hair and abnormal tooth morphology. This has been attributed to a semi-dominant 7-base-pair duplication in the first exon of the forkhead box I3 gene (FOXI3) shared by all three breeds. Here, we identified this FOXI3 variant in a historical museum sample of pedigreed hairless dog skulls by using ancient DNA extraction and present the associated dental phenotype. Unlike in the coated wild type dogs, the hairless dogs were characterised in both the mandibular and maxillary dentition by a loss of the permanent canines, premolars and to some extent incisors. In addition, the deciduous fourth premolars and permanent first and second molars consistently lacked the distal and lingual cusps; this resulted in only a single enlarged cusp in the basin-like heel (talonid in lower molars, talon in upper molars). This molar phenotype is also found among several living and fossil carnivorans and the extinct order Creodonta in which it is associated with hypercarnivory. We therefore suggest that FOXI3 may generally be involved in dental (cusp) development within and across mammalian lineages including the hominids which are known to exhibit marked variability in the presence of lingual cusps.Kornelius KupczikAlexander CaganSilke BrauerMartin S. FischerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kornelius Kupczik Alexander Cagan Silke Brauer Martin S. Fischer The dental phenotype of hairless dogs with FOXI3 haploinsufficiency
description	Abstract Hairless dog breeds show a form of ectodermal dysplasia characterised by a lack of hair and abnormal tooth morphology. This has been attributed to a semi-dominant 7-base-pair duplication in the first exon of the forkhead box I3 gene (FOXI3) shared by all three breeds. Here, we identified this FOXI3 variant in a historical museum sample of pedigreed hairless dog skulls by using ancient DNA extraction and present the associated dental phenotype. Unlike in the coated wild type dogs, the hairless dogs were characterised in both the mandibular and maxillary dentition by a loss of the permanent canines, premolars and to some extent incisors. In addition, the deciduous fourth premolars and permanent first and second molars consistently lacked the distal and lingual cusps; this resulted in only a single enlarged cusp in the basin-like heel (talonid in lower molars, talon in upper molars). This molar phenotype is also found among several living and fossil carnivorans and the extinct order Creodonta in which it is associated with hypercarnivory. We therefore suggest that FOXI3 may generally be involved in dental (cusp) development within and across mammalian lineages including the hominids which are known to exhibit marked variability in the presence of lingual cusps.
format	article
author	Kornelius Kupczik Alexander Cagan Silke Brauer Martin S. Fischer
author_facet	Kornelius Kupczik Alexander Cagan Silke Brauer Martin S. Fischer
author_sort	Kornelius Kupczik
title	The dental phenotype of hairless dogs with FOXI3 haploinsufficiency
title_short	The dental phenotype of hairless dogs with FOXI3 haploinsufficiency
title_full	The dental phenotype of hairless dogs with FOXI3 haploinsufficiency
title_fullStr	The dental phenotype of hairless dogs with FOXI3 haploinsufficiency
title_full_unstemmed	The dental phenotype of hairless dogs with FOXI3 haploinsufficiency
title_sort	dental phenotype of hairless dogs with foxi3 haploinsufficiency
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/94261aecac0f47f6ac00b8280aefedaa
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The dental phenotype of hairless dogs with FOXI3 haploinsufficiency

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