Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition

Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition

Emopamil-Binding Protein (EBP), is an endoplasmic reticulum membrane protein involved in cholesterol biosynthesis, autophagy and oligodendrocyte formation. Here, authors report two crystal structures of human EBP and identify a pharmacological binding site that accommodates multiple different ligand...

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Autores principales: Tao Long, Abdirahman Hassan, Bonne M Thompson, Jeffrey G McDonald, Jiawei Wang, Xiaochun Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/94264a1396794620b380724e03025384
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