Highlights of Immunomodulation in <i>Salmonella</i>-Based Cancer Therapy

Bacteria-mediated cancer therapy (BMCT) is an emerging tool that may advance potential approaches in cancer immunotherapy, whereby tumors are eradicated by the hosts’ immune system upon recruitment and activation by bacteria such as <i>Salmonella</i>. This paper provides an emphasis on t...

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Autores principales:	Christian R. Pangilinan, Che-Hsin Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Salmonella</i> bacteria-mediated cancer therapy immunomodulation immunotherapy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9428d31d538041d1aafda6b240b557ca
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spelling	oai:doaj.org-article:9428d31d538041d1aafda6b240b557ca2021-11-25T16:49:05ZHighlights of Immunomodulation in <i>Salmonella</i>-Based Cancer Therapy10.3390/biomedicines91115662227-9059https://doaj.org/article/9428d31d538041d1aafda6b240b557ca2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1566https://doaj.org/toc/2227-9059Bacteria-mediated cancer therapy (BMCT) is an emerging tool that may advance potential approaches in cancer immunotherapy, whereby tumors are eradicated by the hosts’ immune system upon recruitment and activation by bacteria such as <i>Salmonella</i>. This paper provides an emphasis on the immunomodulatory effects that encompasses both the innate and adaptive immune responses inherently triggered by <i>Salmonella</i>. Furthermore, modifications of <i>Salmonella</i>-based treatment in the attempt to improve tumor-specific immune responses including cytokine therapy, gene therapy, and DNA vaccine delivery are likewise discussed. The majority of the findings described herein incorporate cell-based experiments and murine model studies, and only a few accounts describe clinical trials. <i>Salmonella</i>-based cancer therapy is still under development; nonetheless, the pre-clinical research and early-phase clinical trials that have been completed so far have shown promising and convincing results. Certainly, the continuous development of, and innovation on, <i>Salmonella</i>-based therapy could pave the way for its eventual emergence as one of the mainstream therapeutic interventions addressing various types of cancer.Christian R. PangilinanChe-Hsin LeeMDPI AGarticle<i>Salmonella</i>bacteria-mediated cancer therapyimmunomodulationimmunotherapyBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1566, p 1566 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Salmonella</i> bacteria-mediated cancer therapy immunomodulation immunotherapy Biology (General) QH301-705.5
spellingShingle	<i>Salmonella</i> bacteria-mediated cancer therapy immunomodulation immunotherapy Biology (General) QH301-705.5 Christian R. Pangilinan Che-Hsin Lee Highlights of Immunomodulation in <i>Salmonella</i>-Based Cancer Therapy
description	Bacteria-mediated cancer therapy (BMCT) is an emerging tool that may advance potential approaches in cancer immunotherapy, whereby tumors are eradicated by the hosts’ immune system upon recruitment and activation by bacteria such as <i>Salmonella</i>. This paper provides an emphasis on the immunomodulatory effects that encompasses both the innate and adaptive immune responses inherently triggered by <i>Salmonella</i>. Furthermore, modifications of <i>Salmonella</i>-based treatment in the attempt to improve tumor-specific immune responses including cytokine therapy, gene therapy, and DNA vaccine delivery are likewise discussed. The majority of the findings described herein incorporate cell-based experiments and murine model studies, and only a few accounts describe clinical trials. <i>Salmonella</i>-based cancer therapy is still under development; nonetheless, the pre-clinical research and early-phase clinical trials that have been completed so far have shown promising and convincing results. Certainly, the continuous development of, and innovation on, <i>Salmonella</i>-based therapy could pave the way for its eventual emergence as one of the mainstream therapeutic interventions addressing various types of cancer.
format	article
author	Christian R. Pangilinan Che-Hsin Lee
author_facet	Christian R. Pangilinan Che-Hsin Lee
author_sort	Christian R. Pangilinan
title	Highlights of Immunomodulation in <i>Salmonella</i>-Based Cancer Therapy
title_short	Highlights of Immunomodulation in <i>Salmonella</i>-Based Cancer Therapy
title_full	Highlights of Immunomodulation in <i>Salmonella</i>-Based Cancer Therapy
title_fullStr	Highlights of Immunomodulation in <i>Salmonella</i>-Based Cancer Therapy
title_full_unstemmed	Highlights of Immunomodulation in <i>Salmonella</i>-Based Cancer Therapy
title_sort	highlights of immunomodulation in <i>salmonella</i>-based cancer therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9428d31d538041d1aafda6b240b557ca
work_keys_str_mv	AT christianrpangilinan highlightsofimmunomodulationinisalmonellaibasedcancertherapy AT chehsinlee highlightsofimmunomodulationinisalmonellaibasedcancertherapy
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Highlights of Immunomodulation in <i>Salmonella</i>-Based Cancer Therapy

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