Contemplating stem cell therapy for epilepsy-induced neuropsychiatric symptoms

Gautam Rao, Sherwin Mashkouri, David Aum, Paul Marcet, Cesar V Borlongan Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA Abstract: Epilepsy is a debilitating disease that impacts m...

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Autores principales:	Rao G, Mashkouri S, Aum D, Marcet P, Borlongan CV
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Epilepsy neuropsychiatric stem cells autologous Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9428ea44aaa340bea4b989a3bcb6999d
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spelling	oai:doaj.org-article:9428ea44aaa340bea4b989a3bcb6999d2021-12-02T00:07:26ZContemplating stem cell therapy for epilepsy-induced neuropsychiatric symptoms1178-2021https://doaj.org/article/9428ea44aaa340bea4b989a3bcb6999d2017-02-01T00:00:00Zhttps://www.dovepress.com/contemplating-stem-cell-therapy-for-epilepsy-induced-neuropsychiatric--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Gautam Rao, Sherwin Mashkouri, David Aum, Paul Marcet, Cesar V Borlongan Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA Abstract: Epilepsy is a debilitating disease that impacts millions of people worldwide. While unprovoked seizures characterize its cardinal symptom, an important aspect of epilepsy that remains to be addressed is the neuropsychiatric component. It has been documented for millennia in paintings and literature that those with epilepsy can suffer from bouts of aggression, depression, and other psychiatric ailments. Current treatments for epilepsy include the use of antiepileptic drugs and surgical resection. Antiepileptic drugs reduce the overall firing of the brain to mitigate the rate of seizure occurrence. Surgery aims to remove a portion of the brain that is suspected to be the source of aberrant firing that leads to seizures. Both options treat the seizure-generating neurological aspect of epilepsy, but fail to directly address the neuropsychiatric components. A promising new treatment for epilepsy is the use of stem cells to treat both the biological and psychiatric components. Stem cell therapy has been shown efficacious in treating experimental models of neurological disorders, including Parkinson’s disease, and neuropsychiatric diseases, such as depression. Additional research is necessary to see if stem cells can treat both neurological and neuropsychiatric aspects of epilepsy. Currently, there is no animal model that recapitulates all the clinical hallmarks of epilepsy. This could be due to difficulty in characterizing the neuropsychiatric component of the disease. In advancing stem cell therapy for treating epilepsy, experimental testing of the safety and efficacy of allogeneic and autologous transplantation will require the optimization of cell dosage, delivery, and timing of transplantation in a clinically relevant model of epilepsy with both neurological and neuropsychiatric symptoms of the disease as the primary outcome measures. Keywords: epilepsy, neuropsychiatric, stem cells, autologous Rao GMashkouri SAum DMarcet PBorlongan CVDove Medical PressarticleEpilepsyneuropsychiatricstem cellsautologousNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 585-596 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Epilepsy neuropsychiatric stem cells autologous Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Epilepsy neuropsychiatric stem cells autologous Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Rao G Mashkouri S Aum D Marcet P Borlongan CV Contemplating stem cell therapy for epilepsy-induced neuropsychiatric symptoms
description	Gautam Rao, Sherwin Mashkouri, David Aum, Paul Marcet, Cesar V Borlongan Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA Abstract: Epilepsy is a debilitating disease that impacts millions of people worldwide. While unprovoked seizures characterize its cardinal symptom, an important aspect of epilepsy that remains to be addressed is the neuropsychiatric component. It has been documented for millennia in paintings and literature that those with epilepsy can suffer from bouts of aggression, depression, and other psychiatric ailments. Current treatments for epilepsy include the use of antiepileptic drugs and surgical resection. Antiepileptic drugs reduce the overall firing of the brain to mitigate the rate of seizure occurrence. Surgery aims to remove a portion of the brain that is suspected to be the source of aberrant firing that leads to seizures. Both options treat the seizure-generating neurological aspect of epilepsy, but fail to directly address the neuropsychiatric components. A promising new treatment for epilepsy is the use of stem cells to treat both the biological and psychiatric components. Stem cell therapy has been shown efficacious in treating experimental models of neurological disorders, including Parkinson’s disease, and neuropsychiatric diseases, such as depression. Additional research is necessary to see if stem cells can treat both neurological and neuropsychiatric aspects of epilepsy. Currently, there is no animal model that recapitulates all the clinical hallmarks of epilepsy. This could be due to difficulty in characterizing the neuropsychiatric component of the disease. In advancing stem cell therapy for treating epilepsy, experimental testing of the safety and efficacy of allogeneic and autologous transplantation will require the optimization of cell dosage, delivery, and timing of transplantation in a clinically relevant model of epilepsy with both neurological and neuropsychiatric symptoms of the disease as the primary outcome measures. Keywords: epilepsy, neuropsychiatric, stem cells, autologous
format	article
author	Rao G Mashkouri S Aum D Marcet P Borlongan CV
author_facet	Rao G Mashkouri S Aum D Marcet P Borlongan CV
author_sort	Rao G
title	Contemplating stem cell therapy for epilepsy-induced neuropsychiatric symptoms
title_short	Contemplating stem cell therapy for epilepsy-induced neuropsychiatric symptoms
title_full	Contemplating stem cell therapy for epilepsy-induced neuropsychiatric symptoms
title_fullStr	Contemplating stem cell therapy for epilepsy-induced neuropsychiatric symptoms
title_full_unstemmed	Contemplating stem cell therapy for epilepsy-induced neuropsychiatric symptoms
title_sort	contemplating stem cell therapy for epilepsy-induced neuropsychiatric symptoms
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/9428ea44aaa340bea4b989a3bcb6999d
work_keys_str_mv	AT raog contemplatingstemcelltherapyforepilepsyinducedneuropsychiatricsymptoms AT mashkouris contemplatingstemcelltherapyforepilepsyinducedneuropsychiatricsymptoms AT aumd contemplatingstemcelltherapyforepilepsyinducedneuropsychiatricsymptoms AT marcetp contemplatingstemcelltherapyforepilepsyinducedneuropsychiatricsymptoms AT borlongancv contemplatingstemcelltherapyforepilepsyinducedneuropsychiatricsymptoms
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Contemplating stem cell therapy for epilepsy-induced neuropsychiatric symptoms

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