Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

Memory T cells are vital responders to skin inflammation, but cell localization and dynamics of exchange with the bloodstream are not clear. Here the authors use parabiosis and intravital microscopy to show that CD4+memory T cells equilibrate with the circulation and cluster around hair follicles in...

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Autores principales:	Nicholas Collins, Xiaodong Jiang, Ali Zaid, Bethany L. Macleod, Jane Li, Chang Ook Park, Ashraful Haque, Sammy Bedoui, William R. Heath, Scott N. Mueller, Thomas S. Kupper, Thomas Gebhardt, Francis R. Carbone
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9429c534091c48ec9b67d0bb26d4ecdf
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spelling	oai:doaj.org-article:9429c534091c48ec9b67d0bb26d4ecdf2021-12-02T15:35:25ZSkin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation10.1038/ncomms115142041-1723https://doaj.org/article/9429c534091c48ec9b67d0bb26d4ecdf2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11514https://doaj.org/toc/2041-1723Memory T cells are vital responders to skin inflammation, but cell localization and dynamics of exchange with the bloodstream are not clear. Here the authors use parabiosis and intravital microscopy to show that CD4+memory T cells equilibrate with the circulation and cluster around hair follicles in response to CCL5-dependent responses to viral infection or contact sensitization.Nicholas CollinsXiaodong JiangAli ZaidBethany L. MacleodJane LiChang Ook ParkAshraful HaqueSammy BedouiWilliam R. HeathScott N. MuellerThomas S. KupperThomas GebhardtFrancis R. CarboneNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas Collins Xiaodong Jiang Ali Zaid Bethany L. Macleod Jane Li Chang Ook Park Ashraful Haque Sammy Bedoui William R. Heath Scott N. Mueller Thomas S. Kupper Thomas Gebhardt Francis R. Carbone Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
description	Memory T cells are vital responders to skin inflammation, but cell localization and dynamics of exchange with the bloodstream are not clear. Here the authors use parabiosis and intravital microscopy to show that CD4+memory T cells equilibrate with the circulation and cluster around hair follicles in response to CCL5-dependent responses to viral infection or contact sensitization.
format	article
author	Nicholas Collins Xiaodong Jiang Ali Zaid Bethany L. Macleod Jane Li Chang Ook Park Ashraful Haque Sammy Bedoui William R. Heath Scott N. Mueller Thomas S. Kupper Thomas Gebhardt Francis R. Carbone
author_facet	Nicholas Collins Xiaodong Jiang Ali Zaid Bethany L. Macleod Jane Li Chang Ook Park Ashraful Haque Sammy Bedoui William R. Heath Scott N. Mueller Thomas S. Kupper Thomas Gebhardt Francis R. Carbone
author_sort	Nicholas Collins
title	Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
title_short	Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
title_full	Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
title_fullStr	Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
title_full_unstemmed	Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
title_sort	skin cd4+ memory t cells exhibit combined cluster-mediated retention and equilibration with the circulation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9429c534091c48ec9b67d0bb26d4ecdf
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Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

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