Defective transcription elongation in a subset of cancers confers immunotherapy resistance

Transcription elongation (TE) is a key point of inducible gene expression regulation. Here, the authors report widespread TE defects (TEdeff) in a high proportion of cancers that correlate with poor immunotherapy response, highlighting TE defects as potential routes for immune resistance.

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Autores principales:	Vishnu Modur, Navneet Singh, Vakul Mohanty, Eunah Chung, Belal Muhammad, Kwangmin Choi, Xiaoting Chen, Kashish Chetal, Nancy Ratner, Nathan Salomonis, Matthew T. Weirauch, Susan Waltz, Gang Huang, Lisa Privette-Vinnedge, Joo-Seop Park, Edith M. Janssen, Kakajan Komurov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/942ee42acc244ca2beabb5d1cf1d3a26
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spelling	oai:doaj.org-article:942ee42acc244ca2beabb5d1cf1d3a262021-12-02T17:32:16ZDefective transcription elongation in a subset of cancers confers immunotherapy resistance10.1038/s41467-018-06810-02041-1723https://doaj.org/article/942ee42acc244ca2beabb5d1cf1d3a262018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06810-0https://doaj.org/toc/2041-1723Transcription elongation (TE) is a key point of inducible gene expression regulation. Here, the authors report widespread TE defects (TEdeff) in a high proportion of cancers that correlate with poor immunotherapy response, highlighting TE defects as potential routes for immune resistance.Vishnu ModurNavneet SinghVakul MohantyEunah ChungBelal MuhammadKwangmin ChoiXiaoting ChenKashish ChetalNancy RatnerNathan SalomonisMatthew T. WeirauchSusan WaltzGang HuangLisa Privette-VinnedgeJoo-Seop ParkEdith M. JanssenKakajan KomurovNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vishnu Modur Navneet Singh Vakul Mohanty Eunah Chung Belal Muhammad Kwangmin Choi Xiaoting Chen Kashish Chetal Nancy Ratner Nathan Salomonis Matthew T. Weirauch Susan Waltz Gang Huang Lisa Privette-Vinnedge Joo-Seop Park Edith M. Janssen Kakajan Komurov Defective transcription elongation in a subset of cancers confers immunotherapy resistance
description	Transcription elongation (TE) is a key point of inducible gene expression regulation. Here, the authors report widespread TE defects (TEdeff) in a high proportion of cancers that correlate with poor immunotherapy response, highlighting TE defects as potential routes for immune resistance.
format	article
author	Vishnu Modur Navneet Singh Vakul Mohanty Eunah Chung Belal Muhammad Kwangmin Choi Xiaoting Chen Kashish Chetal Nancy Ratner Nathan Salomonis Matthew T. Weirauch Susan Waltz Gang Huang Lisa Privette-Vinnedge Joo-Seop Park Edith M. Janssen Kakajan Komurov
author_facet	Vishnu Modur Navneet Singh Vakul Mohanty Eunah Chung Belal Muhammad Kwangmin Choi Xiaoting Chen Kashish Chetal Nancy Ratner Nathan Salomonis Matthew T. Weirauch Susan Waltz Gang Huang Lisa Privette-Vinnedge Joo-Seop Park Edith M. Janssen Kakajan Komurov
author_sort	Vishnu Modur
title	Defective transcription elongation in a subset of cancers confers immunotherapy resistance
title_short	Defective transcription elongation in a subset of cancers confers immunotherapy resistance
title_full	Defective transcription elongation in a subset of cancers confers immunotherapy resistance
title_fullStr	Defective transcription elongation in a subset of cancers confers immunotherapy resistance
title_full_unstemmed	Defective transcription elongation in a subset of cancers confers immunotherapy resistance
title_sort	defective transcription elongation in a subset of cancers confers immunotherapy resistance
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/942ee42acc244ca2beabb5d1cf1d3a26
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Defective transcription elongation in a subset of cancers confers immunotherapy resistance

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