The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis

Long term estrogen deprivation can result in apoptosis in breast cancer cells. Here, the authors show that this apoptosis is induced by the long-range chromatin interaction of loci containing the ESR1 and FOXO 3 genes, resulting in FOXO 3-mediated apoptosis.

Guardado en:

Detalles Bibliográficos
Autores principales:	Mohamed Osama Ali Abdalla, Tatsuro Yamamoto, Kazumitsu Maehara, Jumpei Nogami, Yasuyuki Ohkawa, Hisashi Miura, Rawin Poonperm, Ichiro Hiratani, Hideki Nakayama, Mitsuyoshi Nakao, Noriko Saitoh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/942f290119a6494eac46f39607ac50db
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:942f290119a6494eac46f39607ac50db
record_format	dspace
spelling	oai:doaj.org-article:942f290119a6494eac46f39607ac50db2021-12-02T17:02:18ZThe Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis10.1038/s41467-019-11378-42041-1723https://doaj.org/article/942f290119a6494eac46f39607ac50db2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11378-4https://doaj.org/toc/2041-1723Long term estrogen deprivation can result in apoptosis in breast cancer cells. Here, the authors show that this apoptosis is induced by the long-range chromatin interaction of loci containing the ESR1 and FOXO 3 genes, resulting in FOXO 3-mediated apoptosis.Mohamed Osama Ali AbdallaTatsuro YamamotoKazumitsu MaeharaJumpei NogamiYasuyuki OhkawaHisashi MiuraRawin PoonpermIchiro HirataniHideki NakayamaMitsuyoshi NakaoNoriko SaitohNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mohamed Osama Ali Abdalla Tatsuro Yamamoto Kazumitsu Maehara Jumpei Nogami Yasuyuki Ohkawa Hisashi Miura Rawin Poonperm Ichiro Hiratani Hideki Nakayama Mitsuyoshi Nakao Noriko Saitoh The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis
description	Long term estrogen deprivation can result in apoptosis in breast cancer cells. Here, the authors show that this apoptosis is induced by the long-range chromatin interaction of loci containing the ESR1 and FOXO 3 genes, resulting in FOXO 3-mediated apoptosis.
format	article
author	Mohamed Osama Ali Abdalla Tatsuro Yamamoto Kazumitsu Maehara Jumpei Nogami Yasuyuki Ohkawa Hisashi Miura Rawin Poonperm Ichiro Hiratani Hideki Nakayama Mitsuyoshi Nakao Noriko Saitoh
author_facet	Mohamed Osama Ali Abdalla Tatsuro Yamamoto Kazumitsu Maehara Jumpei Nogami Yasuyuki Ohkawa Hisashi Miura Rawin Poonperm Ichiro Hiratani Hideki Nakayama Mitsuyoshi Nakao Noriko Saitoh
author_sort	Mohamed Osama Ali Abdalla
title	The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis
title_short	The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis
title_full	The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis
title_fullStr	The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis
title_full_unstemmed	The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis
title_sort	eleanor ncrnas activate the topological domain of the esr1 locus to balance against apoptosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/942f290119a6494eac46f39607ac50db
work_keys_str_mv	AT mohamedosamaaliabdalla theeleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT tatsuroyamamoto theeleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT kazumitsumaehara theeleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT jumpeinogami theeleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT yasuyukiohkawa theeleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT hisashimiura theeleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT rawinpoonperm theeleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT ichirohiratani theeleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT hidekinakayama theeleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT mitsuyoshinakao theeleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT norikosaitoh theeleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT mohamedosamaaliabdalla eleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT tatsuroyamamoto eleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT kazumitsumaehara eleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT jumpeinogami eleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT yasuyukiohkawa eleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT hisashimiura eleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT rawinpoonperm eleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT ichirohiratani eleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT hidekinakayama eleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT mitsuyoshinakao eleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis AT norikosaitoh eleanorncrnasactivatethetopologicaldomainoftheesr1locustobalanceagainstapoptosis
_version_	1718381920377634816

The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis

Ejemplares similares