Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells

Wolbachia infection of mosquitoes can block dengue virus infection and is tested in field trials, but the mechanism of action is unclear. Using proteomics, Geoghegan et al. here identify effects of Wolbachia on cholesterol homeostasis and dengue virus replication in Aedes aegypti.

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Autores principales:	Vincent Geoghegan, Kirsty Stainton, Stephanie M. Rainey, Thomas H. Ant, Adam A. Dowle, Tony Larson, Svenja Hester, Philip D. Charles, Benjamin Thomas, Steven P. Sinkins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/942fa8266843463fb169fb68685ce5c2
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spelling	oai:doaj.org-article:942fa8266843463fb169fb68685ce5c22021-12-02T14:42:18ZPerturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells10.1038/s41467-017-00610-82041-1723https://doaj.org/article/942fa8266843463fb169fb68685ce5c22017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00610-8https://doaj.org/toc/2041-1723Wolbachia infection of mosquitoes can block dengue virus infection and is tested in field trials, but the mechanism of action is unclear. Using proteomics, Geoghegan et al. here identify effects of Wolbachia on cholesterol homeostasis and dengue virus replication in Aedes aegypti.Vincent GeogheganKirsty StaintonStephanie M. RaineyThomas H. AntAdam A. DowleTony LarsonSvenja HesterPhilip D. CharlesBenjamin ThomasSteven P. SinkinsNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vincent Geoghegan Kirsty Stainton Stephanie M. Rainey Thomas H. Ant Adam A. Dowle Tony Larson Svenja Hester Philip D. Charles Benjamin Thomas Steven P. Sinkins Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells
description	Wolbachia infection of mosquitoes can block dengue virus infection and is tested in field trials, but the mechanism of action is unclear. Using proteomics, Geoghegan et al. here identify effects of Wolbachia on cholesterol homeostasis and dengue virus replication in Aedes aegypti.
format	article
author	Vincent Geoghegan Kirsty Stainton Stephanie M. Rainey Thomas H. Ant Adam A. Dowle Tony Larson Svenja Hester Philip D. Charles Benjamin Thomas Steven P. Sinkins
author_facet	Vincent Geoghegan Kirsty Stainton Stephanie M. Rainey Thomas H. Ant Adam A. Dowle Tony Larson Svenja Hester Philip D. Charles Benjamin Thomas Steven P. Sinkins
author_sort	Vincent Geoghegan
title	Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells
title_short	Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells
title_full	Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells
title_fullStr	Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells
title_full_unstemmed	Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells
title_sort	perturbed cholesterol and vesicular trafficking associated with dengue blocking in wolbachia-infected aedes aegypti cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/942fa8266843463fb169fb68685ce5c2
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Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells

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