A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus

Genedrives bias the inheritance of alleles in diploid organisms. Here, the authors develop a gene-drive analogous system for bacteria, selectively editing and clearing plasmids.

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Detalles Bibliográficos
Autores principales: J. Andrés Valderrama, Surashree S. Kulkarni, Victor Nizet, Ethan Bier
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/9431fcda4911459db05b6a180743da80
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Descripción
Sumario:Genedrives bias the inheritance of alleles in diploid organisms. Here, the authors develop a gene-drive analogous system for bacteria, selectively editing and clearing plasmids.