A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus

Genedrives bias the inheritance of alleles in diploid organisms. Here, the authors develop a gene-drive analogous system for bacteria, selectively editing and clearing plasmids.

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Autores principales:	J. Andrés Valderrama, Surashree S. Kulkarni, Victor Nizet, Ethan Bier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9431fcda4911459db05b6a180743da80
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spelling	oai:doaj.org-article:9431fcda4911459db05b6a180743da802021-12-02T17:01:28ZA bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus10.1038/s41467-019-13649-62041-1723https://doaj.org/article/9431fcda4911459db05b6a180743da802019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13649-6https://doaj.org/toc/2041-1723Genedrives bias the inheritance of alleles in diploid organisms. Here, the authors develop a gene-drive analogous system for bacteria, selectively editing and clearing plasmids.J. Andrés ValderramaSurashree S. KulkarniVictor NizetEthan BierNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q J. Andrés Valderrama Surashree S. Kulkarni Victor Nizet Ethan Bier A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus
description	Genedrives bias the inheritance of alleles in diploid organisms. Here, the authors develop a gene-drive analogous system for bacteria, selectively editing and clearing plasmids.
format	article
author	J. Andrés Valderrama Surashree S. Kulkarni Victor Nizet Ethan Bier
author_facet	J. Andrés Valderrama Surashree S. Kulkarni Victor Nizet Ethan Bier
author_sort	J. Andrés Valderrama
title	A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus
title_short	A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus
title_full	A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus
title_fullStr	A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus
title_full_unstemmed	A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus
title_sort	bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9431fcda4911459db05b6a180743da80
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A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus

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