Genetic and phenotypic analysis of the causal relationship between aging and COVID-19

Ying et al. conduct a multi-instrument Mendelian randomization study looking at the link between aging and COVID-19 risk. They observe an association between genetic variation implicated in longevity and decreased risk of COVID-19 infection and hospitalization, with Notch signaling and immune system...

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Autores principales: Kejun Ying, Ranran Zhai, Timothy V. Pyrkov, Anastasia V. Shindyapina, Marco Mariotti, Peter O. Fedichev, Xia Shen, Vadim N. Gladyshev
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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R
Acceso en línea:https://doaj.org/article/9432b47b0f474ab28368a68b3468e756
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Sumario:Ying et al. conduct a multi-instrument Mendelian randomization study looking at the link between aging and COVID-19 risk. They observe an association between genetic variation implicated in longevity and decreased risk of COVID-19 infection and hospitalization, with Notch signaling and immune system development loci found to be important in aging-related COVID-19 risk.