Genetic and phenotypic analysis of the causal relationship between aging and COVID-19

Ying et al. conduct a multi-instrument Mendelian randomization study looking at the link between aging and COVID-19 risk. They observe an association between genetic variation implicated in longevity and decreased risk of COVID-19 infection and hospitalization, with Notch signaling and immune system...

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Autores principales:	Kejun Ying, Ranran Zhai, Timothy V. Pyrkov, Anastasia V. Shindyapina, Marco Mariotti, Peter O. Fedichev, Xia Shen, Vadim N. Gladyshev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/9432b47b0f474ab28368a68b3468e756
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spelling	oai:doaj.org-article:9432b47b0f474ab28368a68b3468e7562021-12-02T17:13:16ZGenetic and phenotypic analysis of the causal relationship between aging and COVID-1910.1038/s43856-021-00033-z2730-664Xhttps://doaj.org/article/9432b47b0f474ab28368a68b3468e7562021-10-01T00:00:00Zhttps://doi.org/10.1038/s43856-021-00033-zhttps://doaj.org/toc/2730-664XYing et al. conduct a multi-instrument Mendelian randomization study looking at the link between aging and COVID-19 risk. They observe an association between genetic variation implicated in longevity and decreased risk of COVID-19 infection and hospitalization, with Notch signaling and immune system development loci found to be important in aging-related COVID-19 risk.Kejun YingRanran ZhaiTimothy V. PyrkovAnastasia V. ShindyapinaMarco MariottiPeter O. FedichevXia ShenVadim N. GladyshevNature PortfolioarticleMedicineRENCommunications Medicine, Vol 1, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Kejun Ying Ranran Zhai Timothy V. Pyrkov Anastasia V. Shindyapina Marco Mariotti Peter O. Fedichev Xia Shen Vadim N. Gladyshev Genetic and phenotypic analysis of the causal relationship between aging and COVID-19
description	Ying et al. conduct a multi-instrument Mendelian randomization study looking at the link between aging and COVID-19 risk. They observe an association between genetic variation implicated in longevity and decreased risk of COVID-19 infection and hospitalization, with Notch signaling and immune system development loci found to be important in aging-related COVID-19 risk.
format	article
author	Kejun Ying Ranran Zhai Timothy V. Pyrkov Anastasia V. Shindyapina Marco Mariotti Peter O. Fedichev Xia Shen Vadim N. Gladyshev
author_facet	Kejun Ying Ranran Zhai Timothy V. Pyrkov Anastasia V. Shindyapina Marco Mariotti Peter O. Fedichev Xia Shen Vadim N. Gladyshev
author_sort	Kejun Ying
title	Genetic and phenotypic analysis of the causal relationship between aging and COVID-19
title_short	Genetic and phenotypic analysis of the causal relationship between aging and COVID-19
title_full	Genetic and phenotypic analysis of the causal relationship between aging and COVID-19
title_fullStr	Genetic and phenotypic analysis of the causal relationship between aging and COVID-19
title_full_unstemmed	Genetic and phenotypic analysis of the causal relationship between aging and COVID-19
title_sort	genetic and phenotypic analysis of the causal relationship between aging and covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9432b47b0f474ab28368a68b3468e756
work_keys_str_mv	AT kejunying geneticandphenotypicanalysisofthecausalrelationshipbetweenagingandcovid19 AT ranranzhai geneticandphenotypicanalysisofthecausalrelationshipbetweenagingandcovid19 AT timothyvpyrkov geneticandphenotypicanalysisofthecausalrelationshipbetweenagingandcovid19 AT anastasiavshindyapina geneticandphenotypicanalysisofthecausalrelationshipbetweenagingandcovid19 AT marcomariotti geneticandphenotypicanalysisofthecausalrelationshipbetweenagingandcovid19 AT peterofedichev geneticandphenotypicanalysisofthecausalrelationshipbetweenagingandcovid19 AT xiashen geneticandphenotypicanalysisofthecausalrelationshipbetweenagingandcovid19 AT vadimngladyshev geneticandphenotypicanalysisofthecausalrelationshipbetweenagingandcovid19
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Genetic and phenotypic analysis of the causal relationship between aging and COVID-19

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