Prognostic value of routine laboratory variables in prediction of breast cancer recurrence

Abstract The prognostic value of routine laboratory variables in breast cancer has been largely overlooked. Based on laboratory tests commonly performed in clinical practice, we aimed to develop a new model to predict disease free survival (DFS) after surgical removal of primary breast cancer. In a...

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Autores principales:	Zhu Zhu, Ling Li, Zhong Ye, Tong Fu, Ye Du, Aiping Shi, Di Wu, Ke Li, Yifan Zhu, Chun Wang, Zhimin Fan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/94342027ca124bdba4b2c09baebde682
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spelling	oai:doaj.org-article:94342027ca124bdba4b2c09baebde6822021-12-02T12:30:11ZPrognostic value of routine laboratory variables in prediction of breast cancer recurrence10.1038/s41598-017-08240-22045-2322https://doaj.org/article/94342027ca124bdba4b2c09baebde6822017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08240-2https://doaj.org/toc/2045-2322Abstract The prognostic value of routine laboratory variables in breast cancer has been largely overlooked. Based on laboratory tests commonly performed in clinical practice, we aimed to develop a new model to predict disease free survival (DFS) after surgical removal of primary breast cancer. In a cohort of 1,596 breast cancer patients, we analyzed the associations of 33 laboratory variables with patient DFS. Based on 3 significant laboratory variables (hemoglobin, alkaline phosphatase, and international normalized ratio), together with important demographic and clinical variables, we developed a prognostic model, achieving the area under the curve of 0.79. We categorized patients into 3 risk groups according to the prognostic index developed from the final model. Compared with the patients in the low-risk group, those in the medium- and high-risk group had a significantly increased risk of recurrence with a hazard ratio (HR) of 1.75 (95% confidence interval [CI] 1.30–2.38) and 4.66 (95% CI 3.54–6.14), respectively. The results from the training set were validated in the testing set. Overall, our prognostic model incorporating readily available routine laboratory tests is powerful in identifying breast cancer patients who are at high risk of recurrence. Further study is warranted to validate its clinical application.Zhu ZhuLing LiZhong YeTong FuYe DuAiping ShiDi WuKe LiYifan ZhuChun WangZhimin FanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhu Zhu Ling Li Zhong Ye Tong Fu Ye Du Aiping Shi Di Wu Ke Li Yifan Zhu Chun Wang Zhimin Fan Prognostic value of routine laboratory variables in prediction of breast cancer recurrence
description	Abstract The prognostic value of routine laboratory variables in breast cancer has been largely overlooked. Based on laboratory tests commonly performed in clinical practice, we aimed to develop a new model to predict disease free survival (DFS) after surgical removal of primary breast cancer. In a cohort of 1,596 breast cancer patients, we analyzed the associations of 33 laboratory variables with patient DFS. Based on 3 significant laboratory variables (hemoglobin, alkaline phosphatase, and international normalized ratio), together with important demographic and clinical variables, we developed a prognostic model, achieving the area under the curve of 0.79. We categorized patients into 3 risk groups according to the prognostic index developed from the final model. Compared with the patients in the low-risk group, those in the medium- and high-risk group had a significantly increased risk of recurrence with a hazard ratio (HR) of 1.75 (95% confidence interval [CI] 1.30–2.38) and 4.66 (95% CI 3.54–6.14), respectively. The results from the training set were validated in the testing set. Overall, our prognostic model incorporating readily available routine laboratory tests is powerful in identifying breast cancer patients who are at high risk of recurrence. Further study is warranted to validate its clinical application.
format	article
author	Zhu Zhu Ling Li Zhong Ye Tong Fu Ye Du Aiping Shi Di Wu Ke Li Yifan Zhu Chun Wang Zhimin Fan
author_facet	Zhu Zhu Ling Li Zhong Ye Tong Fu Ye Du Aiping Shi Di Wu Ke Li Yifan Zhu Chun Wang Zhimin Fan
author_sort	Zhu Zhu
title	Prognostic value of routine laboratory variables in prediction of breast cancer recurrence
title_short	Prognostic value of routine laboratory variables in prediction of breast cancer recurrence
title_full	Prognostic value of routine laboratory variables in prediction of breast cancer recurrence
title_fullStr	Prognostic value of routine laboratory variables in prediction of breast cancer recurrence
title_full_unstemmed	Prognostic value of routine laboratory variables in prediction of breast cancer recurrence
title_sort	prognostic value of routine laboratory variables in prediction of breast cancer recurrence
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/94342027ca124bdba4b2c09baebde682
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Prognostic value of routine laboratory variables in prediction of breast cancer recurrence

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