Vitamin D status and chronic obstructive pulmonary disease: a prospective general population study.

<h4>Objectives</h4>Vitamin D deficiency is common among persons with chronic obstructive pulmonary disease (COPD). Whether vitamin D affects the development and deterioration of COPD or is a consequence of the disease lacks clarity. We investigated the association between vitamin D statu...

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Autores principales:	Tea Skaaby, Lise Lotte Nystrup Husemoen, Betina Heinsbæk Thuesen, Charlotta Pisinger, Torben Jørgensen, Runa Vavia Fenger, Allan Linneberg
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/943551e03ed24ce3bb6ed75d7501954d
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spelling	oai:doaj.org-article:943551e03ed24ce3bb6ed75d7501954d2021-11-18T08:29:54ZVitamin D status and chronic obstructive pulmonary disease: a prospective general population study.1932-620310.1371/journal.pone.0090654https://doaj.org/article/943551e03ed24ce3bb6ed75d7501954d2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24594696/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>Vitamin D deficiency is common among persons with chronic obstructive pulmonary disease (COPD). Whether vitamin D affects the development and deterioration of COPD or is a consequence of the disease lacks clarity. We investigated the association between vitamin D status and prevalent and incident COPD in the general population.<h4>Methods</h4>We included a total of 12,041 individuals from three general population studies conducted in 1993-94, 1999-2001, and 2006-2008, respectively, with vitamin D measurements. Information on COPD was obtained from the Danish National Patient Register and The Danish Registry of Causes of Death.<h4>Results</h4>There were 85 prevalent and 463 incident cases of COPD (median follow-up 9.7 years). We found a statistically significant inverse association between vitamin D status and prevalent COPD with odds ratio = 0.89 (95% confidence interval, CI: 0.79, 1.0), but no statistically significant association with incident COPD with a hazard ratio = 0.98 (95% CI: 0.94, 1.0), respectively, per 10 nmol/l higher vitamin D status, when adjusted for possible confounders.<h4>Conclusions</h4>We found a statistically significant inverse cross-sectional association between vitamin D status and COPD, but no association between vitamin D status and incident COPD.Tea SkaabyLise Lotte Nystrup HusemoenBetina Heinsbæk ThuesenCharlotta PisingerTorben JørgensenRuna Vavia FengerAllan LinnebergPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e90654 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tea Skaaby Lise Lotte Nystrup Husemoen Betina Heinsbæk Thuesen Charlotta Pisinger Torben Jørgensen Runa Vavia Fenger Allan Linneberg Vitamin D status and chronic obstructive pulmonary disease: a prospective general population study.
description	<h4>Objectives</h4>Vitamin D deficiency is common among persons with chronic obstructive pulmonary disease (COPD). Whether vitamin D affects the development and deterioration of COPD or is a consequence of the disease lacks clarity. We investigated the association between vitamin D status and prevalent and incident COPD in the general population.<h4>Methods</h4>We included a total of 12,041 individuals from three general population studies conducted in 1993-94, 1999-2001, and 2006-2008, respectively, with vitamin D measurements. Information on COPD was obtained from the Danish National Patient Register and The Danish Registry of Causes of Death.<h4>Results</h4>There were 85 prevalent and 463 incident cases of COPD (median follow-up 9.7 years). We found a statistically significant inverse association between vitamin D status and prevalent COPD with odds ratio = 0.89 (95% confidence interval, CI: 0.79, 1.0), but no statistically significant association with incident COPD with a hazard ratio = 0.98 (95% CI: 0.94, 1.0), respectively, per 10 nmol/l higher vitamin D status, when adjusted for possible confounders.<h4>Conclusions</h4>We found a statistically significant inverse cross-sectional association between vitamin D status and COPD, but no association between vitamin D status and incident COPD.
format	article
author	Tea Skaaby Lise Lotte Nystrup Husemoen Betina Heinsbæk Thuesen Charlotta Pisinger Torben Jørgensen Runa Vavia Fenger Allan Linneberg
author_facet	Tea Skaaby Lise Lotte Nystrup Husemoen Betina Heinsbæk Thuesen Charlotta Pisinger Torben Jørgensen Runa Vavia Fenger Allan Linneberg
author_sort	Tea Skaaby
title	Vitamin D status and chronic obstructive pulmonary disease: a prospective general population study.
title_short	Vitamin D status and chronic obstructive pulmonary disease: a prospective general population study.
title_full	Vitamin D status and chronic obstructive pulmonary disease: a prospective general population study.
title_fullStr	Vitamin D status and chronic obstructive pulmonary disease: a prospective general population study.
title_full_unstemmed	Vitamin D status and chronic obstructive pulmonary disease: a prospective general population study.
title_sort	vitamin d status and chronic obstructive pulmonary disease: a prospective general population study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/943551e03ed24ce3bb6ed75d7501954d
work_keys_str_mv	AT teaskaaby vitamindstatusandchronicobstructivepulmonarydiseaseaprospectivegeneralpopulationstudy AT liselottenystruphusemoen vitamindstatusandchronicobstructivepulmonarydiseaseaprospectivegeneralpopulationstudy AT betinaheinsbækthuesen vitamindstatusandchronicobstructivepulmonarydiseaseaprospectivegeneralpopulationstudy AT charlottapisinger vitamindstatusandchronicobstructivepulmonarydiseaseaprospectivegeneralpopulationstudy AT torbenjørgensen vitamindstatusandchronicobstructivepulmonarydiseaseaprospectivegeneralpopulationstudy AT runavaviafenger vitamindstatusandchronicobstructivepulmonarydiseaseaprospectivegeneralpopulationstudy AT allanlinneberg vitamindstatusandchronicobstructivepulmonarydiseaseaprospectivegeneralpopulationstudy
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Vitamin D status and chronic obstructive pulmonary disease: a prospective general population study.

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