General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism
Preclinical studies suggest that repeated exposure to anesthetics during a critical period of neurodevelopment induces long-term changes in synaptic transmission, plasticity, and behavior. Such changes are of great concern, as similar changes have also been identified in animal models of neurodevelo...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/9436549645464bc4884e790161b1c88c |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:9436549645464bc4884e790161b1c88c |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:9436549645464bc4884e790161b1c88c2021-12-01T13:59:13ZGeneral Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism1662-510210.3389/fncel.2021.772047https://doaj.org/article/9436549645464bc4884e790161b1c88c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fncel.2021.772047/fullhttps://doaj.org/toc/1662-5102Preclinical studies suggest that repeated exposure to anesthetics during a critical period of neurodevelopment induces long-term changes in synaptic transmission, plasticity, and behavior. Such changes are of great concern, as similar changes have also been identified in animal models of neurodevelopmental disorders (NDDs) such as autism. Because of overlapping synaptic changes, it is also possible that anesthetic exposures have a more significant effect in individuals diagnosed with NDDs. Thus, we evaluated the effects of early, multiple anesthetic exposures in BTBR mice, an inbred strain that displays autistic behavior. We discovered that three cycles of sevoflurane anesthesia (2.5%, 1 h) with 2-h intervals between each exposure in late postnatal BTBR mice did not aggravate, but instead improved pathophysiological mechanisms involved with autistic behavior. Sevoflurane exposures restored E/I balance (by increasing inhibitory synaptic transmission), and increased mitochondrial respiration and BDNF signaling in BTBR mice. Most importantly, such changes were associated with reduced autistic behavior in BTBR mice, as sociability was increased in the three-chamber test and repetitive behavior was reduced in the self-grooming test. Our results suggest that anesthetic exposures during neurodevelopment may affect individuals diagnosed with NDDs differently.Jianchen CuiJianchen CuiJianchen CuiJianchen CuiJianchen CuiJiho ParkXianshu JuXianshu JuXianshu JuYulim LeeYulim LeeYulim LeeYulim LeeBoohwi HongBoohwi HongJeonghoon AhnYoon Hee KimYoon Hee KimYoungkwon KoYoungkwon KoSeok-Hwa YoonSeok-Hwa YoonChaeseong LimChaeseong LimSun Yeul LeeSun Yeul LeeSung-Oh HuhJun Young HeoJun Young HeoJun Young HeoWoosuk ChungWoosuk ChungWoosuk ChungWoosuk ChungFrontiers Media S.A.articleautismanesthesiaBDNF (brain derived neurotrophic factor)BTBRE/I imbalancemitochondrial respirationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Cellular Neuroscience, Vol 15 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
autism anesthesia BDNF (brain derived neurotrophic factor) BTBR E/I imbalance mitochondrial respiration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
| spellingShingle |
autism anesthesia BDNF (brain derived neurotrophic factor) BTBR E/I imbalance mitochondrial respiration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jianchen Cui Jianchen Cui Jianchen Cui Jianchen Cui Jianchen Cui Jiho Park Xianshu Ju Xianshu Ju Xianshu Ju Yulim Lee Yulim Lee Yulim Lee Yulim Lee Boohwi Hong Boohwi Hong Jeonghoon Ahn Yoon Hee Kim Yoon Hee Kim Youngkwon Ko Youngkwon Ko Seok-Hwa Yoon Seok-Hwa Yoon Chaeseong Lim Chaeseong Lim Sun Yeul Lee Sun Yeul Lee Sung-Oh Huh Jun Young Heo Jun Young Heo Jun Young Heo Woosuk Chung Woosuk Chung Woosuk Chung Woosuk Chung General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism |
| description |
Preclinical studies suggest that repeated exposure to anesthetics during a critical period of neurodevelopment induces long-term changes in synaptic transmission, plasticity, and behavior. Such changes are of great concern, as similar changes have also been identified in animal models of neurodevelopmental disorders (NDDs) such as autism. Because of overlapping synaptic changes, it is also possible that anesthetic exposures have a more significant effect in individuals diagnosed with NDDs. Thus, we evaluated the effects of early, multiple anesthetic exposures in BTBR mice, an inbred strain that displays autistic behavior. We discovered that three cycles of sevoflurane anesthesia (2.5%, 1 h) with 2-h intervals between each exposure in late postnatal BTBR mice did not aggravate, but instead improved pathophysiological mechanisms involved with autistic behavior. Sevoflurane exposures restored E/I balance (by increasing inhibitory synaptic transmission), and increased mitochondrial respiration and BDNF signaling in BTBR mice. Most importantly, such changes were associated with reduced autistic behavior in BTBR mice, as sociability was increased in the three-chamber test and repetitive behavior was reduced in the self-grooming test. Our results suggest that anesthetic exposures during neurodevelopment may affect individuals diagnosed with NDDs differently. |
| format |
article |
| author |
Jianchen Cui Jianchen Cui Jianchen Cui Jianchen Cui Jianchen Cui Jiho Park Xianshu Ju Xianshu Ju Xianshu Ju Yulim Lee Yulim Lee Yulim Lee Yulim Lee Boohwi Hong Boohwi Hong Jeonghoon Ahn Yoon Hee Kim Yoon Hee Kim Youngkwon Ko Youngkwon Ko Seok-Hwa Yoon Seok-Hwa Yoon Chaeseong Lim Chaeseong Lim Sun Yeul Lee Sun Yeul Lee Sung-Oh Huh Jun Young Heo Jun Young Heo Jun Young Heo Woosuk Chung Woosuk Chung Woosuk Chung Woosuk Chung |
| author_facet |
Jianchen Cui Jianchen Cui Jianchen Cui Jianchen Cui Jianchen Cui Jiho Park Xianshu Ju Xianshu Ju Xianshu Ju Yulim Lee Yulim Lee Yulim Lee Yulim Lee Boohwi Hong Boohwi Hong Jeonghoon Ahn Yoon Hee Kim Yoon Hee Kim Youngkwon Ko Youngkwon Ko Seok-Hwa Yoon Seok-Hwa Yoon Chaeseong Lim Chaeseong Lim Sun Yeul Lee Sun Yeul Lee Sung-Oh Huh Jun Young Heo Jun Young Heo Jun Young Heo Woosuk Chung Woosuk Chung Woosuk Chung Woosuk Chung |
| author_sort |
Jianchen Cui |
| title |
General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism |
| title_short |
General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism |
| title_full |
General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism |
| title_fullStr |
General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism |
| title_full_unstemmed |
General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism |
| title_sort |
general anesthesia during neurodevelopment reduces autistic behavior in adult btbr mice, a murine model of autism |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/9436549645464bc4884e790161b1c88c |
| work_keys_str_mv |
AT jianchencui generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT jianchencui generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT jianchencui generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT jianchencui generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT jianchencui generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT jihopark generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT xianshuju generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT xianshuju generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT xianshuju generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT yulimlee generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT yulimlee generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT yulimlee generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT yulimlee generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT boohwihong generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT boohwihong generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT jeonghoonahn generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT yoonheekim generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT yoonheekim generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT youngkwonko generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT youngkwonko generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT seokhwayoon generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT seokhwayoon generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT chaeseonglim generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT chaeseonglim generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT sunyeullee generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT sunyeullee generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT sungohhuh generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT junyoungheo generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT junyoungheo generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT junyoungheo generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT woosukchung generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT woosukchung generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT woosukchung generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism AT woosukchung generalanesthesiaduringneurodevelopmentreducesautisticbehaviorinadultbtbrmiceamurinemodelofautism |
| _version_ |
1718405073040572416 |