Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo

Abstract In this prospective study of an in-vivo cervical examination using optical coherence tomography (OCT), we evaluated the diagnostic value of non-invasive and real-time OCT in cervical precancerous lesions and cancer diagnosis, and determined the characteristics of OCT images. 733 patients fr...

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Autores principales:	Chenchen Ren, Xianxu Zeng, Zhongna Shi, Chunyan Wang, Huifen Wang, Xiuqin Wang, Baoping Zhang, Zhaoning Jiang, Huan Ma, Hao Hu, Haozhe Piao, Xiaoan Zhang, Baojin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/943b02649c12449b9e08e9f55bde3b99
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spelling	oai:doaj.org-article:943b02649c12449b9e08e9f55bde3b992021-12-02T14:37:14ZMulti-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo10.1038/s41598-021-86711-32045-2322https://doaj.org/article/943b02649c12449b9e08e9f55bde3b992021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86711-3https://doaj.org/toc/2045-2322Abstract In this prospective study of an in-vivo cervical examination using optical coherence tomography (OCT), we evaluated the diagnostic value of non-invasive and real-time OCT in cervical precancerous lesions and cancer diagnosis, and determined the characteristics of OCT images. 733 patients from 5 Chinese hospitals were inspected with OCT and colposcopy-directed biopsy. The OCT images were compared with the histological sections to find out the characteristics of various categories of lesions. The OCT images were also interpreted by 3 investigators to make a 2-class classification, and the results were compared against the pathological results. Various structures of the cervical tissue were clearly observed in OCT images, which matched well with the corresponding histological sections. The OCT diagnosis results delivered a sensitivity of 87.0% (95% confidence interval, CI 82.2–90.7%), a specificity of 84.1% (95% CI 80.3–87.2%), and an overall accuracy of 85.1%. Both good consistency of OCT images and histological images and satisfactory diagnosis results were provided by OCT. Due to its features of non-invasion, real-time, and accuracy, OCT is valuable for the in-vivo evaluation of cervical lesions and has the potential to be one of the routine cervical diagnosis methods.Chenchen RenXianxu ZengZhongna ShiChunyan WangHuifen WangXiuqin WangBaoping ZhangZhaoning JiangHuan MaHao HuHaozhe PiaoXiaoan ZhangBaojin WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chenchen Ren Xianxu Zeng Zhongna Shi Chunyan Wang Huifen Wang Xiuqin Wang Baoping Zhang Zhaoning Jiang Huan Ma Hao Hu Haozhe Piao Xiaoan Zhang Baojin Wang Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo
description	Abstract In this prospective study of an in-vivo cervical examination using optical coherence tomography (OCT), we evaluated the diagnostic value of non-invasive and real-time OCT in cervical precancerous lesions and cancer diagnosis, and determined the characteristics of OCT images. 733 patients from 5 Chinese hospitals were inspected with OCT and colposcopy-directed biopsy. The OCT images were compared with the histological sections to find out the characteristics of various categories of lesions. The OCT images were also interpreted by 3 investigators to make a 2-class classification, and the results were compared against the pathological results. Various structures of the cervical tissue were clearly observed in OCT images, which matched well with the corresponding histological sections. The OCT diagnosis results delivered a sensitivity of 87.0% (95% confidence interval, CI 82.2–90.7%), a specificity of 84.1% (95% CI 80.3–87.2%), and an overall accuracy of 85.1%. Both good consistency of OCT images and histological images and satisfactory diagnosis results were provided by OCT. Due to its features of non-invasion, real-time, and accuracy, OCT is valuable for the in-vivo evaluation of cervical lesions and has the potential to be one of the routine cervical diagnosis methods.
format	article
author	Chenchen Ren Xianxu Zeng Zhongna Shi Chunyan Wang Huifen Wang Xiuqin Wang Baoping Zhang Zhaoning Jiang Huan Ma Hao Hu Haozhe Piao Xiaoan Zhang Baojin Wang
author_facet	Chenchen Ren Xianxu Zeng Zhongna Shi Chunyan Wang Huifen Wang Xiuqin Wang Baoping Zhang Zhaoning Jiang Huan Ma Hao Hu Haozhe Piao Xiaoan Zhang Baojin Wang
author_sort	Chenchen Ren
title	Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo
title_short	Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo
title_full	Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo
title_fullStr	Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo
title_full_unstemmed	Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo
title_sort	multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/943b02649c12449b9e08e9f55bde3b99
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Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo

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