Parallel G-quadruplexes recruit the HSV-1 transcription factor ICP4 to promote viral transcription in herpes virus-infected human cells
Ilaria Frasson et al. find that the herpesvirus major transcription factor ICP4 regulates viral gene expression and replication through binding to parallel DNA G-quadruplexes (G4s). These results suggest that drugs targeting G4s at ICP4-regulated gene promoters could be an effective antiviral strate...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/943c4355795a4746b380351fd6fd43ff |
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| Sumario: | Ilaria Frasson et al. find that the herpesvirus major transcription factor ICP4 regulates viral gene expression and replication through binding to parallel DNA G-quadruplexes (G4s). These results suggest that drugs targeting G4s at ICP4-regulated gene promoters could be an effective antiviral strategy. |
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