Parallel G-quadruplexes recruit the HSV-1 transcription factor ICP4 to promote viral transcription in herpes virus-infected human cells

Ilaria Frasson et al. find that the herpesvirus major transcription factor ICP4 regulates viral gene expression and replication through binding to parallel DNA G-quadruplexes (G4s). These results suggest that drugs targeting G4s at ICP4-regulated gene promoters could be an effective antiviral strate...

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Autores principales:	Ilaria Frasson, Paola Soldà, Matteo Nadai, Sara Lago, Sara N. Richter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/943c4355795a4746b380351fd6fd43ff
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spelling	oai:doaj.org-article:943c4355795a4746b380351fd6fd43ff2021-12-02T13:40:50ZParallel G-quadruplexes recruit the HSV-1 transcription factor ICP4 to promote viral transcription in herpes virus-infected human cells10.1038/s42003-021-02035-y2399-3642https://doaj.org/article/943c4355795a4746b380351fd6fd43ff2021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02035-yhttps://doaj.org/toc/2399-3642Ilaria Frasson et al. find that the herpesvirus major transcription factor ICP4 regulates viral gene expression and replication through binding to parallel DNA G-quadruplexes (G4s). These results suggest that drugs targeting G4s at ICP4-regulated gene promoters could be an effective antiviral strategy.Ilaria FrassonPaola SoldàMatteo NadaiSara LagoSara N. RichterNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ilaria Frasson Paola Soldà Matteo Nadai Sara Lago Sara N. Richter Parallel G-quadruplexes recruit the HSV-1 transcription factor ICP4 to promote viral transcription in herpes virus-infected human cells
description	Ilaria Frasson et al. find that the herpesvirus major transcription factor ICP4 regulates viral gene expression and replication through binding to parallel DNA G-quadruplexes (G4s). These results suggest that drugs targeting G4s at ICP4-regulated gene promoters could be an effective antiviral strategy.
format	article
author	Ilaria Frasson Paola Soldà Matteo Nadai Sara Lago Sara N. Richter
author_facet	Ilaria Frasson Paola Soldà Matteo Nadai Sara Lago Sara N. Richter
author_sort	Ilaria Frasson
title	Parallel G-quadruplexes recruit the HSV-1 transcription factor ICP4 to promote viral transcription in herpes virus-infected human cells
title_short	Parallel G-quadruplexes recruit the HSV-1 transcription factor ICP4 to promote viral transcription in herpes virus-infected human cells
title_full	Parallel G-quadruplexes recruit the HSV-1 transcription factor ICP4 to promote viral transcription in herpes virus-infected human cells
title_fullStr	Parallel G-quadruplexes recruit the HSV-1 transcription factor ICP4 to promote viral transcription in herpes virus-infected human cells
title_full_unstemmed	Parallel G-quadruplexes recruit the HSV-1 transcription factor ICP4 to promote viral transcription in herpes virus-infected human cells
title_sort	parallel g-quadruplexes recruit the hsv-1 transcription factor icp4 to promote viral transcription in herpes virus-infected human cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/943c4355795a4746b380351fd6fd43ff
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Parallel G-quadruplexes recruit the HSV-1 transcription factor ICP4 to promote viral transcription in herpes virus-infected human cells

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