hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma

RNA G-quadruplexes (RG4s) have been functionally linked to cancer gene expression. Here, Herviou, Le Bras et al. have identified the protein machinery modulating RG4s and reveal the role and mechanism of hnRNP H/F and DHX36 in RG4-mediated translational regulation affecting cancer treatment in gliob...

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Autores principales:	Pauline Herviou, Morgane Le Bras, Leïla Dumas, Corinne Hieblot, Julia Gilhodes, Gianluca Cioci, Jean-Philippe Hugnot, Alfred Ameadan, François Guillonneau, Erik Dassi, Anne Cammas, Stefania Millevoi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/943f94a9317e43c69d93a0684d2b3375
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spelling	oai:doaj.org-article:943f94a9317e43c69d93a0684d2b33752021-12-02T14:49:16ZhnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma10.1038/s41467-020-16168-x2041-1723https://doaj.org/article/943f94a9317e43c69d93a0684d2b33752020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16168-xhttps://doaj.org/toc/2041-1723RNA G-quadruplexes (RG4s) have been functionally linked to cancer gene expression. Here, Herviou, Le Bras et al. have identified the protein machinery modulating RG4s and reveal the role and mechanism of hnRNP H/F and DHX36 in RG4-mediated translational regulation affecting cancer treatment in glioblastoma.Pauline HerviouMorgane Le BrasLeïla DumasCorinne HieblotJulia GilhodesGianluca CiociJean-Philippe HugnotAlfred AmeadanFrançois GuillonneauErik DassiAnne CammasStefania MillevoiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pauline Herviou Morgane Le Bras Leïla Dumas Corinne Hieblot Julia Gilhodes Gianluca Cioci Jean-Philippe Hugnot Alfred Ameadan François Guillonneau Erik Dassi Anne Cammas Stefania Millevoi hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma
description	RNA G-quadruplexes (RG4s) have been functionally linked to cancer gene expression. Here, Herviou, Le Bras et al. have identified the protein machinery modulating RG4s and reveal the role and mechanism of hnRNP H/F and DHX36 in RG4-mediated translational regulation affecting cancer treatment in glioblastoma.
format	article
author	Pauline Herviou Morgane Le Bras Leïla Dumas Corinne Hieblot Julia Gilhodes Gianluca Cioci Jean-Philippe Hugnot Alfred Ameadan François Guillonneau Erik Dassi Anne Cammas Stefania Millevoi
author_facet	Pauline Herviou Morgane Le Bras Leïla Dumas Corinne Hieblot Julia Gilhodes Gianluca Cioci Jean-Philippe Hugnot Alfred Ameadan François Guillonneau Erik Dassi Anne Cammas Stefania Millevoi
author_sort	Pauline Herviou
title	hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma
title_short	hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma
title_full	hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma
title_fullStr	hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma
title_full_unstemmed	hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma
title_sort	hnrnp h/f drive rna g-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/943f94a9317e43c69d93a0684d2b3375
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hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma

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