CAN SERUM KL-6 LEVEL BE USED AS A MARKER IN LUNG METASTASIS OF BONE SARCOMAS?

Objective: Osteosarcoma and Ewing sarcoma are the most common bone sarcomas of the childhood. Kerbs von de Lungren 6 (KL-6) is a glycoprotein that is expressed on type 2 pneumocytes and bronchial epithelium. Serum KL-6 level can increase in many interstitial pulmonary diseas and lung cancers. Aim of...

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Autores principales:	Turan BAYHAN, Neriman SARI, Selma ÇAKMAKCI, Seda ŞAHİN, İnci İLHAN, Nazan ÇİLEDAĞ
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/94423b0842ec4deeac48fdb9f5a8ebf2
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spelling	oai:doaj.org-article:94423b0842ec4deeac48fdb9f5a8ebf22021-11-10T04:34:14ZCAN SERUM KL-6 LEVEL BE USED AS A MARKER IN LUNG METASTASIS OF BONE SARCOMAS?2531-137910.1016/j.htct.2021.10.1006https://doaj.org/article/94423b0842ec4deeac48fdb9f5a8ebf22021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137921011536https://doaj.org/toc/2531-1379Objective: Osteosarcoma and Ewing sarcoma are the most common bone sarcomas of the childhood. Kerbs von de Lungren 6 (KL-6) is a glycoprotein that is expressed on type 2 pneumocytes and bronchial epithelium. Serum KL-6 level can increase in many interstitial pulmonary diseas and lung cancers. Aim of the study is to evaluate the predictive value of serum KL-6 level on malign potential of pulmonary nodules in pediatric patients with bone sarcoma with pulmonary metastasis or with vague pulmonary nodules. Methodology: Blood samples were taken from patients with diagnosis of Ewing sarcoma or osteosarcoma at the time of diagnosis or first relapses. Control group was selected from 42 voluntary children without any chronic or acute diseases associated with lung. Serum of the blood samples were separated and frozen at -70 C˚ and KL-6 level was measured via ELISA method. Thorax computed tomography (CT) images of the patients were analyzed to interpret about pulmonary metastasis. Results: Total 47 patients were included in the study, 19 of the patients were with Ewing sarcoma and 28 with osteosarcoma.Thorax CT revealed pulmonary metastasis in 9 of the patients at first evaluation. KL-6 level of the these patients with pulmonary metastasis was greater than without metastasis (p;0.05) and control group (p;0.019). Patients with pulmonary nodule at any time had significantly higher serum KL-6 level at first evaluation than without metastasis (p; 0.04) and control group (p;0.017). Conclusion: In our study we found serum KL-6 level higher in patients with pulmonary nodules that relevant with pulmonary sarcoma metastasis than patients without metastasis and healthy control group. Our study also revealed that patients that had pulmonary metastasis during their follow-up also had higher KL-6 level at diagnosis. These results should be proven with more number of patients. Measuring KL-6 level may be used as a marker for early diagnosis of pulmonary sarcoma metastasis.Turan BAYHANNeriman SARISelma ÇAKMAKCISeda ŞAHİNİnci İLHANNazan ÇİLEDAĞElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S30-S31 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Turan BAYHAN Neriman SARI Selma ÇAKMAKCI Seda ŞAHİN İnci İLHAN Nazan ÇİLEDAĞ CAN SERUM KL-6 LEVEL BE USED AS A MARKER IN LUNG METASTASIS OF BONE SARCOMAS?
description	Objective: Osteosarcoma and Ewing sarcoma are the most common bone sarcomas of the childhood. Kerbs von de Lungren 6 (KL-6) is a glycoprotein that is expressed on type 2 pneumocytes and bronchial epithelium. Serum KL-6 level can increase in many interstitial pulmonary diseas and lung cancers. Aim of the study is to evaluate the predictive value of serum KL-6 level on malign potential of pulmonary nodules in pediatric patients with bone sarcoma with pulmonary metastasis or with vague pulmonary nodules. Methodology: Blood samples were taken from patients with diagnosis of Ewing sarcoma or osteosarcoma at the time of diagnosis or first relapses. Control group was selected from 42 voluntary children without any chronic or acute diseases associated with lung. Serum of the blood samples were separated and frozen at -70 C˚ and KL-6 level was measured via ELISA method. Thorax computed tomography (CT) images of the patients were analyzed to interpret about pulmonary metastasis. Results: Total 47 patients were included in the study, 19 of the patients were with Ewing sarcoma and 28 with osteosarcoma.Thorax CT revealed pulmonary metastasis in 9 of the patients at first evaluation. KL-6 level of the these patients with pulmonary metastasis was greater than without metastasis (p;0.05) and control group (p;0.019). Patients with pulmonary nodule at any time had significantly higher serum KL-6 level at first evaluation than without metastasis (p; 0.04) and control group (p;0.017). Conclusion: In our study we found serum KL-6 level higher in patients with pulmonary nodules that relevant with pulmonary sarcoma metastasis than patients without metastasis and healthy control group. Our study also revealed that patients that had pulmonary metastasis during their follow-up also had higher KL-6 level at diagnosis. These results should be proven with more number of patients. Measuring KL-6 level may be used as a marker for early diagnosis of pulmonary sarcoma metastasis.
format	article
author	Turan BAYHAN Neriman SARI Selma ÇAKMAKCI Seda ŞAHİN İnci İLHAN Nazan ÇİLEDAĞ
author_facet	Turan BAYHAN Neriman SARI Selma ÇAKMAKCI Seda ŞAHİN İnci İLHAN Nazan ÇİLEDAĞ
author_sort	Turan BAYHAN
title	CAN SERUM KL-6 LEVEL BE USED AS A MARKER IN LUNG METASTASIS OF BONE SARCOMAS?
title_short	CAN SERUM KL-6 LEVEL BE USED AS A MARKER IN LUNG METASTASIS OF BONE SARCOMAS?
title_full	CAN SERUM KL-6 LEVEL BE USED AS A MARKER IN LUNG METASTASIS OF BONE SARCOMAS?
title_fullStr	CAN SERUM KL-6 LEVEL BE USED AS A MARKER IN LUNG METASTASIS OF BONE SARCOMAS?
title_full_unstemmed	CAN SERUM KL-6 LEVEL BE USED AS A MARKER IN LUNG METASTASIS OF BONE SARCOMAS?
title_sort	can serum kl-6 level be used as a marker in lung metastasis of bone sarcomas?
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/94423b0842ec4deeac48fdb9f5a8ebf2
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CAN SERUM KL-6 LEVEL BE USED AS A MARKER IN LUNG METASTASIS OF BONE SARCOMAS?

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