FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell

FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell

The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am demethylase activity, not through internal m6A demethyla...

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Autores principales: Sébastien Relier, Julie Ripoll, Hélène Guillorit, Amandine Amalric, Cyrinne Achour, Florence Boissière, Jérôme Vialaret, Aurore Attina, Françoise Debart, Armelle Choquet, Françoise Macari, Virginie Marchand, Yuri Motorin, Emmanuelle Samalin, Jean-Jacques Vasseur, Julie Pannequin, Francesca Aguilo, Evelyne Lopez-Crapez, Christophe Hirtz, Eric Rivals, Amandine Bastide, Alexandre David
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/9446244d632a4b05a389d98461a70dd7
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spelling oai:doaj.org-article:9446244d632a4b05a389d98461a70dd72021-12-02T11:39:31ZFTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell10.1038/s41467-021-21758-42041-1723https://doaj.org/article/9446244d632a4b05a389d98461a70dd72021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21758-4https://doaj.org/toc/2041-1723The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am demethylase activity, not through internal m6A demethylase activity.Sébastien RelierJulie RipollHélène GuilloritAmandine AmalricCyrinne AchourFlorence BoissièreJérôme VialaretAurore AttinaFrançoise DebartArmelle ChoquetFrançoise MacariVirginie MarchandYuri MotorinEmmanuelle SamalinJean-Jacques VasseurJulie PannequinFrancesca AguiloEvelyne Lopez-CrapezChristophe HirtzEric RivalsAmandine BastideAlexandre DavidNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sébastien Relier
Julie Ripoll
Hélène Guillorit
Amandine Amalric
Cyrinne Achour
Florence Boissière
Jérôme Vialaret
Aurore Attina
Françoise Debart
Armelle Choquet
Françoise Macari
Virginie Marchand
Yuri Motorin
Emmanuelle Samalin
Jean-Jacques Vasseur
Julie Pannequin
Francesca Aguilo
Evelyne Lopez-Crapez
Christophe Hirtz
Eric Rivals
Amandine Bastide
Alexandre David
FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell
description The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am demethylase activity, not through internal m6A demethylase activity.
format article
author Sébastien Relier
Julie Ripoll
Hélène Guillorit
Amandine Amalric
Cyrinne Achour
Florence Boissière
Jérôme Vialaret
Aurore Attina
Françoise Debart
Armelle Choquet
Françoise Macari
Virginie Marchand
Yuri Motorin
Emmanuelle Samalin
Jean-Jacques Vasseur
Julie Pannequin
Francesca Aguilo
Evelyne Lopez-Crapez
Christophe Hirtz
Eric Rivals
Amandine Bastide
Alexandre David
author_facet Sébastien Relier
Julie Ripoll
Hélène Guillorit
Amandine Amalric
Cyrinne Achour
Florence Boissière
Jérôme Vialaret
Aurore Attina
Françoise Debart
Armelle Choquet
Françoise Macari
Virginie Marchand
Yuri Motorin
Emmanuelle Samalin
Jean-Jacques Vasseur
Julie Pannequin
Francesca Aguilo
Evelyne Lopez-Crapez
Christophe Hirtz
Eric Rivals
Amandine Bastide
Alexandre David
author_sort Sébastien Relier
title FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell
title_short FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell
title_full FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell
title_fullStr FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell
title_full_unstemmed FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell
title_sort fto-mediated cytoplasmic m6am demethylation adjusts stem-like properties in colorectal cancer cell
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/9446244d632a4b05a389d98461a70dd7
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