Ventrolateral prefrontal hemodynamic responses in autism spectrum disorder with and without depression.

In clinical settings, autism spectrum disorder (ASD) with comorbid depression is often difficult to diagnose, and should be considered in treatment. However, to our knowledge, no functional imaging study has examined the difference between ASD adolescents with and without comorbid depression. We aim...

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Autores principales:	Toshiyuki Ohtani, Akio Wakabayashi, Chihiro Sutoh, Fumiyo Oshima, Yoshiyuki Hirano, Eiji Shimizu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9447e017579b40119f9efbf5529b23a4
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spelling	oai:doaj.org-article:9447e017579b40119f9efbf5529b23a42021-12-02T20:19:22ZVentrolateral prefrontal hemodynamic responses in autism spectrum disorder with and without depression.1932-620310.1371/journal.pone.0256780https://doaj.org/article/9447e017579b40119f9efbf5529b23a42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256780https://doaj.org/toc/1932-6203In clinical settings, autism spectrum disorder (ASD) with comorbid depression is often difficult to diagnose, and should be considered in treatment. However, to our knowledge, no functional imaging study has examined the difference between ASD adolescents with and without comorbid depression. We aimed to compare the characteristics and prefrontal brain function of ASD with and without depression in order to identify a biological marker that can be used to detect the difference. Twenty-eight drug-naïve adolescents with ASD (14 ASD with and 14 ASD without depression) and 14 age- and gender-matched adolescents with typical development were evaluated using several variables. These included intelligence quotient, autism quotient, depression severity using the Beck Depression Inventory 2nd edition (BDI-II), and level of social functioning using the Social Adaptation Self-evaluation Scale (SASS). In addition, frontotemporal hemodynamic responses during a verbal fluency task (VFT) were measured using functional near-infrared spectroscopy (fNIRS). The ASD group, including both of the ASD with and ASD without depression groups, showed smaller hemodynamic responses than the typical development group in portions of the left dorsolateral prefrontal cortex (DLPFC), bilateral ventrolateral prefrontal cortex (VLPFC) and anterior part of the temporal cortex (aTC) during the VFT. Moreover, the smaller hemodynamic responses in the right VLPFC during the VFT in the ASD group were associated with the worse BDI-II and SASS scores. Furthermore, the ASD with depression group showed smaller hemodynamic responses in the right VLPFC during the VFT than the ASD without depression group in a direct comparison. Adolescents with ASD showed reduced activation in broad frontotemporal regions during a cognitive task compared with those with typical development. More specifically, the right VLPFC activation reflected the level of self-estimated depression and social functioning in the ASD subjects, and could be used to discriminate between ASD adolescents with and without depression.Toshiyuki OhtaniAkio WakabayashiChihiro SutohFumiyo OshimaYoshiyuki HiranoEiji ShimizuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256780 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Toshiyuki Ohtani Akio Wakabayashi Chihiro Sutoh Fumiyo Oshima Yoshiyuki Hirano Eiji Shimizu Ventrolateral prefrontal hemodynamic responses in autism spectrum disorder with and without depression.
description	In clinical settings, autism spectrum disorder (ASD) with comorbid depression is often difficult to diagnose, and should be considered in treatment. However, to our knowledge, no functional imaging study has examined the difference between ASD adolescents with and without comorbid depression. We aimed to compare the characteristics and prefrontal brain function of ASD with and without depression in order to identify a biological marker that can be used to detect the difference. Twenty-eight drug-naïve adolescents with ASD (14 ASD with and 14 ASD without depression) and 14 age- and gender-matched adolescents with typical development were evaluated using several variables. These included intelligence quotient, autism quotient, depression severity using the Beck Depression Inventory 2nd edition (BDI-II), and level of social functioning using the Social Adaptation Self-evaluation Scale (SASS). In addition, frontotemporal hemodynamic responses during a verbal fluency task (VFT) were measured using functional near-infrared spectroscopy (fNIRS). The ASD group, including both of the ASD with and ASD without depression groups, showed smaller hemodynamic responses than the typical development group in portions of the left dorsolateral prefrontal cortex (DLPFC), bilateral ventrolateral prefrontal cortex (VLPFC) and anterior part of the temporal cortex (aTC) during the VFT. Moreover, the smaller hemodynamic responses in the right VLPFC during the VFT in the ASD group were associated with the worse BDI-II and SASS scores. Furthermore, the ASD with depression group showed smaller hemodynamic responses in the right VLPFC during the VFT than the ASD without depression group in a direct comparison. Adolescents with ASD showed reduced activation in broad frontotemporal regions during a cognitive task compared with those with typical development. More specifically, the right VLPFC activation reflected the level of self-estimated depression and social functioning in the ASD subjects, and could be used to discriminate between ASD adolescents with and without depression.
format	article
author	Toshiyuki Ohtani Akio Wakabayashi Chihiro Sutoh Fumiyo Oshima Yoshiyuki Hirano Eiji Shimizu
author_facet	Toshiyuki Ohtani Akio Wakabayashi Chihiro Sutoh Fumiyo Oshima Yoshiyuki Hirano Eiji Shimizu
author_sort	Toshiyuki Ohtani
title	Ventrolateral prefrontal hemodynamic responses in autism spectrum disorder with and without depression.
title_short	Ventrolateral prefrontal hemodynamic responses in autism spectrum disorder with and without depression.
title_full	Ventrolateral prefrontal hemodynamic responses in autism spectrum disorder with and without depression.
title_fullStr	Ventrolateral prefrontal hemodynamic responses in autism spectrum disorder with and without depression.
title_full_unstemmed	Ventrolateral prefrontal hemodynamic responses in autism spectrum disorder with and without depression.
title_sort	ventrolateral prefrontal hemodynamic responses in autism spectrum disorder with and without depression.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9447e017579b40119f9efbf5529b23a4
work_keys_str_mv	AT toshiyukiohtani ventrolateralprefrontalhemodynamicresponsesinautismspectrumdisorderwithandwithoutdepression AT akiowakabayashi ventrolateralprefrontalhemodynamicresponsesinautismspectrumdisorderwithandwithoutdepression AT chihirosutoh ventrolateralprefrontalhemodynamicresponsesinautismspectrumdisorderwithandwithoutdepression AT fumiyooshima ventrolateralprefrontalhemodynamicresponsesinautismspectrumdisorderwithandwithoutdepression AT yoshiyukihirano ventrolateralprefrontalhemodynamicresponsesinautismspectrumdisorderwithandwithoutdepression AT eijishimizu ventrolateralprefrontalhemodynamicresponsesinautismspectrumdisorderwithandwithoutdepression
_version_	1718374241906196480

Ventrolateral prefrontal hemodynamic responses in autism spectrum disorder with and without depression.

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