Mussel-Inspired Carboxymethyl Chitosan Hydrogel Coating of Titanium Alloy with Antibacterial and Bioactive Properties

Infection-related titanium implant failure rates remain exceedingly high in the clinic. Functional surface coating represents a very promising strategy to improve the antibacterial and bioactive properties of titanium alloy implants. Here, we describe a novel bioactive surface coating that consists...

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Autores principales:	Yanru Ren, Xiaoyan Qin, Mike Barbeck, Yi Hou, Haijun Xu, Luo Liu, Chaoyong Liu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	carboxymethyl chitosan gallic acid titanium alloy DMTMM HRP/H<sub>2</sub>O<sub>2</sub> catechol group Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/944b32cc312a48cd8381ee7519dc6425
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spelling	oai:doaj.org-article:944b32cc312a48cd8381ee7519dc64252021-11-25T18:14:34ZMussel-Inspired Carboxymethyl Chitosan Hydrogel Coating of Titanium Alloy with Antibacterial and Bioactive Properties10.3390/ma142269011996-1944https://doaj.org/article/944b32cc312a48cd8381ee7519dc64252021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/22/6901https://doaj.org/toc/1996-1944Infection-related titanium implant failure rates remain exceedingly high in the clinic. Functional surface coating represents a very promising strategy to improve the antibacterial and bioactive properties of titanium alloy implants. Here, we describe a novel bioactive surface coating that consists of a mussel-inspired carboxymethyl chitosan hydrogel loaded with silver nanoparticles (AgNPs) to enhance the bioactive properties of the titanium alloy. The preparation of hydrogel is based on gallic acid grafted carboxymethyl chitosan (CMCS-GA) catalyzed by DMTMM (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride). To build a firm bonding between the hydrogel and titanium alloy plate, a polydopamine layer was introduced onto the surface of the titanium alloy. With HRP/H<sub>2</sub>O<sub>2</sub> catalysis, CMCS-GA can simply form a firm gel layer on the titanium alloy plate through the catechol groups. The surface properties of titanium alloy were characterized by scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), and water contact angle. Silver nanoparticles were loaded into the gel layer by in situ reduction to enhance the antibacterial properties. In vitro antibacterial and cell viability experiments showed that the AgNPs-loaded Ti-gel possesses excellent antibacterial properties and did not affect the proliferation of rabbit mesenchymal stem cells (MSCs).Yanru RenXiaoyan QinMike BarbeckYi HouHaijun XuLuo LiuChaoyong LiuMDPI AGarticlecarboxymethyl chitosangallic acidtitanium alloyDMTMMHRP/H<sub>2</sub>O<sub>2</sub>catechol groupTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6901, p 6901 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carboxymethyl chitosan gallic acid titanium alloy DMTMM HRP/H<sub>2</sub>O<sub>2</sub> catechol group Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	carboxymethyl chitosan gallic acid titanium alloy DMTMM HRP/H<sub>2</sub>O<sub>2</sub> catechol group Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Yanru Ren Xiaoyan Qin Mike Barbeck Yi Hou Haijun Xu Luo Liu Chaoyong Liu Mussel-Inspired Carboxymethyl Chitosan Hydrogel Coating of Titanium Alloy with Antibacterial and Bioactive Properties
description	Infection-related titanium implant failure rates remain exceedingly high in the clinic. Functional surface coating represents a very promising strategy to improve the antibacterial and bioactive properties of titanium alloy implants. Here, we describe a novel bioactive surface coating that consists of a mussel-inspired carboxymethyl chitosan hydrogel loaded with silver nanoparticles (AgNPs) to enhance the bioactive properties of the titanium alloy. The preparation of hydrogel is based on gallic acid grafted carboxymethyl chitosan (CMCS-GA) catalyzed by DMTMM (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride). To build a firm bonding between the hydrogel and titanium alloy plate, a polydopamine layer was introduced onto the surface of the titanium alloy. With HRP/H<sub>2</sub>O<sub>2</sub> catalysis, CMCS-GA can simply form a firm gel layer on the titanium alloy plate through the catechol groups. The surface properties of titanium alloy were characterized by scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), and water contact angle. Silver nanoparticles were loaded into the gel layer by in situ reduction to enhance the antibacterial properties. In vitro antibacterial and cell viability experiments showed that the AgNPs-loaded Ti-gel possesses excellent antibacterial properties and did not affect the proliferation of rabbit mesenchymal stem cells (MSCs).
format	article
author	Yanru Ren Xiaoyan Qin Mike Barbeck Yi Hou Haijun Xu Luo Liu Chaoyong Liu
author_facet	Yanru Ren Xiaoyan Qin Mike Barbeck Yi Hou Haijun Xu Luo Liu Chaoyong Liu
author_sort	Yanru Ren
title	Mussel-Inspired Carboxymethyl Chitosan Hydrogel Coating of Titanium Alloy with Antibacterial and Bioactive Properties
title_short	Mussel-Inspired Carboxymethyl Chitosan Hydrogel Coating of Titanium Alloy with Antibacterial and Bioactive Properties
title_full	Mussel-Inspired Carboxymethyl Chitosan Hydrogel Coating of Titanium Alloy with Antibacterial and Bioactive Properties
title_fullStr	Mussel-Inspired Carboxymethyl Chitosan Hydrogel Coating of Titanium Alloy with Antibacterial and Bioactive Properties
title_full_unstemmed	Mussel-Inspired Carboxymethyl Chitosan Hydrogel Coating of Titanium Alloy with Antibacterial and Bioactive Properties
title_sort	mussel-inspired carboxymethyl chitosan hydrogel coating of titanium alloy with antibacterial and bioactive properties
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/944b32cc312a48cd8381ee7519dc6425
work_keys_str_mv	AT yanruren musselinspiredcarboxymethylchitosanhydrogelcoatingoftitaniumalloywithantibacterialandbioactiveproperties AT xiaoyanqin musselinspiredcarboxymethylchitosanhydrogelcoatingoftitaniumalloywithantibacterialandbioactiveproperties AT mikebarbeck musselinspiredcarboxymethylchitosanhydrogelcoatingoftitaniumalloywithantibacterialandbioactiveproperties AT yihou musselinspiredcarboxymethylchitosanhydrogelcoatingoftitaniumalloywithantibacterialandbioactiveproperties AT haijunxu musselinspiredcarboxymethylchitosanhydrogelcoatingoftitaniumalloywithantibacterialandbioactiveproperties AT luoliu musselinspiredcarboxymethylchitosanhydrogelcoatingoftitaniumalloywithantibacterialandbioactiveproperties AT chaoyongliu musselinspiredcarboxymethylchitosanhydrogelcoatingoftitaniumalloywithantibacterialandbioactiveproperties
_version_	1718411452144943104

Mussel-Inspired Carboxymethyl Chitosan Hydrogel Coating of Titanium Alloy with Antibacterial and Bioactive Properties

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