Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma

Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of lung cancer with poor prognosis. Here the authors performed multi-omics analysis of human samples to investigate the mutational landscape of PSC and show three subgroups of PSC with distinct biology, prognosis and potential therapeutic strat...

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Autores principales: Zhenlin Yang, Jiachen Xu, Lin Li, Renda Li, Yalong Wang, Yanhua Tian, Wei Guo, Zhijie Wang, Fengwei Tan, Jianming Ying, Yuchen Jiao, Shugeng Gao, Jie Wang, Yibo Gao, Jie He
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/9450754d048f4b36a59fec1342fbe22f
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spelling oai:doaj.org-article:9450754d048f4b36a59fec1342fbe22f2021-12-02T17:18:25ZIntegrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma10.1038/s41467-020-18702-32041-1723https://doaj.org/article/9450754d048f4b36a59fec1342fbe22f2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18702-3https://doaj.org/toc/2041-1723Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of lung cancer with poor prognosis. Here the authors performed multi-omics analysis of human samples to investigate the mutational landscape of PSC and show three subgroups of PSC with distinct biology, prognosis and potential therapeutic strategies.Zhenlin YangJiachen XuLin LiRenda LiYalong WangYanhua TianWei GuoZhijie WangFengwei TanJianming YingYuchen JiaoShugeng GaoJie WangYibo GaoJie HeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhenlin Yang
Jiachen Xu
Lin Li
Renda Li
Yalong Wang
Yanhua Tian
Wei Guo
Zhijie Wang
Fengwei Tan
Jianming Ying
Yuchen Jiao
Shugeng Gao
Jie Wang
Yibo Gao
Jie He
Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma
description Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of lung cancer with poor prognosis. Here the authors performed multi-omics analysis of human samples to investigate the mutational landscape of PSC and show three subgroups of PSC with distinct biology, prognosis and potential therapeutic strategies.
format article
author Zhenlin Yang
Jiachen Xu
Lin Li
Renda Li
Yalong Wang
Yanhua Tian
Wei Guo
Zhijie Wang
Fengwei Tan
Jianming Ying
Yuchen Jiao
Shugeng Gao
Jie Wang
Yibo Gao
Jie He
author_facet Zhenlin Yang
Jiachen Xu
Lin Li
Renda Li
Yalong Wang
Yanhua Tian
Wei Guo
Zhijie Wang
Fengwei Tan
Jianming Ying
Yuchen Jiao
Shugeng Gao
Jie Wang
Yibo Gao
Jie He
author_sort Zhenlin Yang
title Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma
title_short Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma
title_full Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma
title_fullStr Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma
title_full_unstemmed Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma
title_sort integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/9450754d048f4b36a59fec1342fbe22f
work_keys_str_mv AT zhenlinyang integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma
AT jiachenxu integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma
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AT jianmingying integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma
AT yuchenjiao integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma
AT shugenggao integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma
AT jiewang integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma
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