Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma
Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of lung cancer with poor prognosis. Here the authors performed multi-omics analysis of human samples to investigate the mutational landscape of PSC and show three subgroups of PSC with distinct biology, prognosis and potential therapeutic strat...
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Nature Portfolio
2020
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oai:doaj.org-article:9450754d048f4b36a59fec1342fbe22f2021-12-02T17:18:25ZIntegrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma10.1038/s41467-020-18702-32041-1723https://doaj.org/article/9450754d048f4b36a59fec1342fbe22f2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18702-3https://doaj.org/toc/2041-1723Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of lung cancer with poor prognosis. Here the authors performed multi-omics analysis of human samples to investigate the mutational landscape of PSC and show three subgroups of PSC with distinct biology, prognosis and potential therapeutic strategies.Zhenlin YangJiachen XuLin LiRenda LiYalong WangYanhua TianWei GuoZhijie WangFengwei TanJianming YingYuchen JiaoShugeng GaoJie WangYibo GaoJie HeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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Science Q Zhenlin Yang Jiachen Xu Lin Li Renda Li Yalong Wang Yanhua Tian Wei Guo Zhijie Wang Fengwei Tan Jianming Ying Yuchen Jiao Shugeng Gao Jie Wang Yibo Gao Jie He Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma |
description |
Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of lung cancer with poor prognosis. Here the authors performed multi-omics analysis of human samples to investigate the mutational landscape of PSC and show three subgroups of PSC with distinct biology, prognosis and potential therapeutic strategies. |
format |
article |
author |
Zhenlin Yang Jiachen Xu Lin Li Renda Li Yalong Wang Yanhua Tian Wei Guo Zhijie Wang Fengwei Tan Jianming Ying Yuchen Jiao Shugeng Gao Jie Wang Yibo Gao Jie He |
author_facet |
Zhenlin Yang Jiachen Xu Lin Li Renda Li Yalong Wang Yanhua Tian Wei Guo Zhijie Wang Fengwei Tan Jianming Ying Yuchen Jiao Shugeng Gao Jie Wang Yibo Gao Jie He |
author_sort |
Zhenlin Yang |
title |
Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma |
title_short |
Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma |
title_full |
Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma |
title_fullStr |
Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma |
title_full_unstemmed |
Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma |
title_sort |
integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/9450754d048f4b36a59fec1342fbe22f |
work_keys_str_mv |
AT zhenlinyang integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma AT jiachenxu integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma AT linli integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma AT rendali integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma AT yalongwang integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma AT yanhuatian integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma AT weiguo integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma AT zhijiewang integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma AT fengweitan integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma AT jianmingying integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma AT yuchenjiao integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma AT shugenggao integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma AT jiewang integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma AT yibogao integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma AT jiehe integratedmolecularcharacterizationrevealspotentialtherapeuticstrategiesforpulmonarysarcomatoidcarcinoma |
_version_ |
1718381098826727424 |