Evaluation of the analgesic potential and safety of Cinnamomum camphora chvar. Borneol essential oil

Cinnamomum camphora chvar. Borneol essential oil (BEO, 18.2% v/v borneol) is a by-product of steam distillation to produce natural crystalline borneol (NCB, 98.4% v/v borneol). Given the known medicinal properties of borneol, the analgesic function and safety were studied. Horn’s method and the Drai...

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Autores principales:	Shanshan Xiao, Hang Yu, Yunfei Xie, Yahui Guo, Jiajia Fan, Weirong Yao
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	acute toxicity analgesia eye irritation pain-related factor skin irritation Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/94512502b69a4f849d06e07c337c7b73
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spelling	oai:doaj.org-article:94512502b69a4f849d06e07c337c7b732021-11-04T15:51:54ZEvaluation of the analgesic potential and safety of Cinnamomum camphora chvar. Borneol essential oil2165-59792165-598710.1080/21655979.2021.1996149https://doaj.org/article/94512502b69a4f849d06e07c337c7b732021-10-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1996149https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Cinnamomum camphora chvar. Borneol essential oil (BEO, 18.2% v/v borneol) is a by-product of steam distillation to produce natural crystalline borneol (NCB, 98.4% v/v borneol). Given the known medicinal properties of borneol, the analgesic function and safety were studied. Horn’s method and the Draize test revealed a gender difference in mice regarding acute oral LD50, i.e., low-toxicity to female mice (2749 mg/kg), but practically non-toxic to male mice (5081 mg/kg). There was no acute and skin or eye irritation when BEO was applied directly, if the BEO concentration was less than 50%. The analgesic effect of BEO was evaluated by the glacial acetic acid-induced writhing pain model. Continuous topical application of BEO to the abdomen of mice for 6 d, significantly reduced observed writhing in mice (p < 0.001) with a strong dose-response relationship (r = -0.9006). Concomitantly, the levels of the serum pain-related mediators, prostaglandin E2 (PGE2) and transient receptor potential melastatin-8 (TRPM8) were significantly reduced (p < 0.001), and the latter showed a strong dose-response relationship (r = -0.9427). Therefore, BEO had similar analgesic functions to borneol and was demonstrated to be safe for medicinal use.Shanshan XiaoHang YuYunfei XieYahui GuoJiajia FanWeirong YaoTaylor & Francis Grouparticleacute toxicityanalgesiaeye irritationpain-related factorskin irritationBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute toxicity analgesia eye irritation pain-related factor skin irritation Biotechnology TP248.13-248.65
spellingShingle	acute toxicity analgesia eye irritation pain-related factor skin irritation Biotechnology TP248.13-248.65 Shanshan Xiao Hang Yu Yunfei Xie Yahui Guo Jiajia Fan Weirong Yao Evaluation of the analgesic potential and safety of Cinnamomum camphora chvar. Borneol essential oil
description	Cinnamomum camphora chvar. Borneol essential oil (BEO, 18.2% v/v borneol) is a by-product of steam distillation to produce natural crystalline borneol (NCB, 98.4% v/v borneol). Given the known medicinal properties of borneol, the analgesic function and safety were studied. Horn’s method and the Draize test revealed a gender difference in mice regarding acute oral LD50, i.e., low-toxicity to female mice (2749 mg/kg), but practically non-toxic to male mice (5081 mg/kg). There was no acute and skin or eye irritation when BEO was applied directly, if the BEO concentration was less than 50%. The analgesic effect of BEO was evaluated by the glacial acetic acid-induced writhing pain model. Continuous topical application of BEO to the abdomen of mice for 6 d, significantly reduced observed writhing in mice (p < 0.001) with a strong dose-response relationship (r = -0.9006). Concomitantly, the levels of the serum pain-related mediators, prostaglandin E2 (PGE2) and transient receptor potential melastatin-8 (TRPM8) were significantly reduced (p < 0.001), and the latter showed a strong dose-response relationship (r = -0.9427). Therefore, BEO had similar analgesic functions to borneol and was demonstrated to be safe for medicinal use.
format	article
author	Shanshan Xiao Hang Yu Yunfei Xie Yahui Guo Jiajia Fan Weirong Yao
author_facet	Shanshan Xiao Hang Yu Yunfei Xie Yahui Guo Jiajia Fan Weirong Yao
author_sort	Shanshan Xiao
title	Evaluation of the analgesic potential and safety of Cinnamomum camphora chvar. Borneol essential oil
title_short	Evaluation of the analgesic potential and safety of Cinnamomum camphora chvar. Borneol essential oil
title_full	Evaluation of the analgesic potential and safety of Cinnamomum camphora chvar. Borneol essential oil
title_fullStr	Evaluation of the analgesic potential and safety of Cinnamomum camphora chvar. Borneol essential oil
title_full_unstemmed	Evaluation of the analgesic potential and safety of Cinnamomum camphora chvar. Borneol essential oil
title_sort	evaluation of the analgesic potential and safety of cinnamomum camphora chvar. borneol essential oil
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/94512502b69a4f849d06e07c337c7b73
work_keys_str_mv	AT shanshanxiao evaluationoftheanalgesicpotentialandsafetyofcinnamomumcamphorachvarborneolessentialoil AT hangyu evaluationoftheanalgesicpotentialandsafetyofcinnamomumcamphorachvarborneolessentialoil AT yunfeixie evaluationoftheanalgesicpotentialandsafetyofcinnamomumcamphorachvarborneolessentialoil AT yahuiguo evaluationoftheanalgesicpotentialandsafetyofcinnamomumcamphorachvarborneolessentialoil AT jiajiafan evaluationoftheanalgesicpotentialandsafetyofcinnamomumcamphorachvarborneolessentialoil AT weirongyao evaluationoftheanalgesicpotentialandsafetyofcinnamomumcamphorachvarborneolessentialoil
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Evaluation of the analgesic potential and safety of Cinnamomum camphora chvar. Borneol essential oil

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