Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease

Coronavirus main protease is essential for viral polyprotein processing and maturation. Here Fu et al. report efficient inhibition of SARS-CoV-2 replication using two inhibitors - Boceprevir and GC376 - targeting the active site of the main viral protease.

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Autores principales:	Lifeng Fu, Fei Ye, Yong Feng, Feng Yu, Qisheng Wang, Yan Wu, Cheng Zhao, Huan Sun, Baoying Huang, Peihua Niu, Hao Song, Yi Shi, Xuebing Li, Wenjie Tan, Jianxun Qi, George Fu Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9457c839815f471c8695c67aa6e95f6c
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spelling	oai:doaj.org-article:9457c839815f471c8695c67aa6e95f6c2021-12-02T15:27:34ZBoth Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease10.1038/s41467-020-18233-x2041-1723https://doaj.org/article/9457c839815f471c8695c67aa6e95f6c2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18233-xhttps://doaj.org/toc/2041-1723Coronavirus main protease is essential for viral polyprotein processing and maturation. Here Fu et al. report efficient inhibition of SARS-CoV-2 replication using two inhibitors - Boceprevir and GC376 - targeting the active site of the main viral protease.Lifeng FuFei YeYong FengFeng YuQisheng WangYan WuCheng ZhaoHuan SunBaoying HuangPeihua NiuHao SongYi ShiXuebing LiWenjie TanJianxun QiGeorge Fu GaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lifeng Fu Fei Ye Yong Feng Feng Yu Qisheng Wang Yan Wu Cheng Zhao Huan Sun Baoying Huang Peihua Niu Hao Song Yi Shi Xuebing Li Wenjie Tan Jianxun Qi George Fu Gao Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease
description	Coronavirus main protease is essential for viral polyprotein processing and maturation. Here Fu et al. report efficient inhibition of SARS-CoV-2 replication using two inhibitors - Boceprevir and GC376 - targeting the active site of the main viral protease.
format	article
author	Lifeng Fu Fei Ye Yong Feng Feng Yu Qisheng Wang Yan Wu Cheng Zhao Huan Sun Baoying Huang Peihua Niu Hao Song Yi Shi Xuebing Li Wenjie Tan Jianxun Qi George Fu Gao
author_facet	Lifeng Fu Fei Ye Yong Feng Feng Yu Qisheng Wang Yan Wu Cheng Zhao Huan Sun Baoying Huang Peihua Niu Hao Song Yi Shi Xuebing Li Wenjie Tan Jianxun Qi George Fu Gao
author_sort	Lifeng Fu
title	Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease
title_short	Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease
title_full	Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease
title_fullStr	Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease
title_full_unstemmed	Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease
title_sort	both boceprevir and gc376 efficaciously inhibit sars-cov-2 by targeting its main protease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9457c839815f471c8695c67aa6e95f6c
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Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease

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