Genetic fusions favor tumorigenesis through degron loss in oncogenes

The impact of genetic fusions on degrons, which are motifs for ubiquitin-mediated protein degradation, has not been fully explored. Here, the authors analyse fusion genes affecting degrons in pan-cancer genomics data, validate their functional impact and find enrichment for both internal and C-termi...

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Autores principales:	Jing Liu, Collin Tokheim, Jonathan D. Lee, Wenjian Gan, Brian J. North, X. Shirley Liu, Pier Paolo Pandolfi, Wenyi Wei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/94598e27d4dd4b42ab93f5a55245e282
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spelling	oai:doaj.org-article:94598e27d4dd4b42ab93f5a55245e2822021-11-21T12:35:25ZGenetic fusions favor tumorigenesis through degron loss in oncogenes10.1038/s41467-021-26871-y2041-1723https://doaj.org/article/94598e27d4dd4b42ab93f5a55245e2822021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26871-yhttps://doaj.org/toc/2041-1723The impact of genetic fusions on degrons, which are motifs for ubiquitin-mediated protein degradation, has not been fully explored. Here, the authors analyse fusion genes affecting degrons in pan-cancer genomics data, validate their functional impact and find enrichment for both internal and C-terminal degron losses.Jing LiuCollin TokheimJonathan D. LeeWenjian GanBrian J. NorthX. Shirley LiuPier Paolo PandolfiWenyi WeiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jing Liu Collin Tokheim Jonathan D. Lee Wenjian Gan Brian J. North X. Shirley Liu Pier Paolo Pandolfi Wenyi Wei Genetic fusions favor tumorigenesis through degron loss in oncogenes
description	The impact of genetic fusions on degrons, which are motifs for ubiquitin-mediated protein degradation, has not been fully explored. Here, the authors analyse fusion genes affecting degrons in pan-cancer genomics data, validate their functional impact and find enrichment for both internal and C-terminal degron losses.
format	article
author	Jing Liu Collin Tokheim Jonathan D. Lee Wenjian Gan Brian J. North X. Shirley Liu Pier Paolo Pandolfi Wenyi Wei
author_facet	Jing Liu Collin Tokheim Jonathan D. Lee Wenjian Gan Brian J. North X. Shirley Liu Pier Paolo Pandolfi Wenyi Wei
author_sort	Jing Liu
title	Genetic fusions favor tumorigenesis through degron loss in oncogenes
title_short	Genetic fusions favor tumorigenesis through degron loss in oncogenes
title_full	Genetic fusions favor tumorigenesis through degron loss in oncogenes
title_fullStr	Genetic fusions favor tumorigenesis through degron loss in oncogenes
title_full_unstemmed	Genetic fusions favor tumorigenesis through degron loss in oncogenes
title_sort	genetic fusions favor tumorigenesis through degron loss in oncogenes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/94598e27d4dd4b42ab93f5a55245e282
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Genetic fusions favor tumorigenesis through degron loss in oncogenes

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