Genetic fusions favor tumorigenesis through degron loss in oncogenes

Genetic fusions favor tumorigenesis through degron loss in oncogenes

The impact of genetic fusions on degrons, which are motifs for ubiquitin-mediated protein degradation, has not been fully explored. Here, the authors analyse fusion genes affecting degrons in pan-cancer genomics data, validate their functional impact and find enrichment for both internal and C-termi...

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Autores principales: Jing Liu, Collin Tokheim, Jonathan D. Lee, Wenjian Gan, Brian J. North, X. Shirley Liu, Pier Paolo Pandolfi, Wenyi Wei
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/94598e27d4dd4b42ab93f5a55245e282
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