In vivo measurement of hippocampal GABAA/cBZR density with [18F]-flumazenil PET for the study of disease progression in an animal model of temporal lobe epilepsy.

In vivo measurement of hippocampal GABAA/cBZR density with [18F]-flumazenil PET for the study of disease progression in an animal model of temporal lobe epilepsy.

<h4>Purpose</h4>Imbalance of inhibitory GABAergic neurotransmission has been proposed to play a role in the pathogenesis of temporal lobe epilepsy (TLE). This study aimed to investigate whether [(18)F]-flumazenil ([(18)F]-FMZ) PET could be used to non-invasively characterise GABAA/centra...

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Autores principales: Lucy Vivash, Marie-Claude Gregoire, Viviane Bouilleret, Alexis Berard, Catriona Wimberley, David Binns, Peter Roselt, Andrew Katsifis, Damian E Myers, Rodney J Hicks, Terence J O'Brien, Stefanie Dedeurwaerdere
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/945b8810b10b40f3a05833d2c064e121
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