Influenza virus transmission is dependent on relative humidity and temperature.

Using the guinea pig as a model host, we show that aerosol spread of influenza virus is dependent upon both ambient relative humidity and temperature. Twenty experiments performed at relative humidities from 20% to 80% and 5 degrees C, 20 degrees C, or 30 degrees C indicated that both cold and dry c...

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Autores principales:	Anice C Lowen, Samira Mubareka, John Steel, Peter Palese
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2007
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9461f54fc1ae40d2b7b0ceb04c555b02
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spelling	oai:doaj.org-article:9461f54fc1ae40d2b7b0ceb04c555b022021-11-25T05:46:22ZInfluenza virus transmission is dependent on relative humidity and temperature.1553-73661553-737410.1371/journal.ppat.0030151https://doaj.org/article/9461f54fc1ae40d2b7b0ceb04c555b022007-10-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.0030151https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Using the guinea pig as a model host, we show that aerosol spread of influenza virus is dependent upon both ambient relative humidity and temperature. Twenty experiments performed at relative humidities from 20% to 80% and 5 degrees C, 20 degrees C, or 30 degrees C indicated that both cold and dry conditions favor transmission. The relationship between transmission via aerosols and relative humidity at 20 degrees C is similar to that previously reported for the stability of influenza viruses (except at high relative humidity, 80%), implying that the effects of humidity act largely at the level of the virus particle. For infected guinea pigs housed at 5 degrees C, the duration of peak shedding was approximately 40 h longer than that of animals housed at 20 degrees C; this increased shedding likely accounts for the enhanced transmission seen at 5 degrees C. To investigate the mechanism permitting prolonged viral growth, expression levels in the upper respiratory tract of several innate immune mediators were determined. Innate responses proved to be comparable between animals housed at 5 degrees C and 20 degrees C, suggesting that cold temperature (5 degrees C) does not impair the innate immune response in this system. Although the seasonal epidemiology of influenza is well characterized, the underlying reasons for predominant wintertime spread are not clear. We provide direct, experimental evidence to support the role of weather conditions in the dynamics of influenza and thereby address a long-standing question fundamental to the understanding of influenza epidemiology and evolution.Anice C LowenSamira MubarekaJohn SteelPeter PalesePublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 3, Iss 10, Pp 1470-1476 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Anice C Lowen Samira Mubareka John Steel Peter Palese Influenza virus transmission is dependent on relative humidity and temperature.
description	Using the guinea pig as a model host, we show that aerosol spread of influenza virus is dependent upon both ambient relative humidity and temperature. Twenty experiments performed at relative humidities from 20% to 80% and 5 degrees C, 20 degrees C, or 30 degrees C indicated that both cold and dry conditions favor transmission. The relationship between transmission via aerosols and relative humidity at 20 degrees C is similar to that previously reported for the stability of influenza viruses (except at high relative humidity, 80%), implying that the effects of humidity act largely at the level of the virus particle. For infected guinea pigs housed at 5 degrees C, the duration of peak shedding was approximately 40 h longer than that of animals housed at 20 degrees C; this increased shedding likely accounts for the enhanced transmission seen at 5 degrees C. To investigate the mechanism permitting prolonged viral growth, expression levels in the upper respiratory tract of several innate immune mediators were determined. Innate responses proved to be comparable between animals housed at 5 degrees C and 20 degrees C, suggesting that cold temperature (5 degrees C) does not impair the innate immune response in this system. Although the seasonal epidemiology of influenza is well characterized, the underlying reasons for predominant wintertime spread are not clear. We provide direct, experimental evidence to support the role of weather conditions in the dynamics of influenza and thereby address a long-standing question fundamental to the understanding of influenza epidemiology and evolution.
format	article
author	Anice C Lowen Samira Mubareka John Steel Peter Palese
author_facet	Anice C Lowen Samira Mubareka John Steel Peter Palese
author_sort	Anice C Lowen
title	Influenza virus transmission is dependent on relative humidity and temperature.
title_short	Influenza virus transmission is dependent on relative humidity and temperature.
title_full	Influenza virus transmission is dependent on relative humidity and temperature.
title_fullStr	Influenza virus transmission is dependent on relative humidity and temperature.
title_full_unstemmed	Influenza virus transmission is dependent on relative humidity and temperature.
title_sort	influenza virus transmission is dependent on relative humidity and temperature.
publisher	Public Library of Science (PLoS)
publishDate	2007
url	https://doaj.org/article/9461f54fc1ae40d2b7b0ceb04c555b02
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Influenza virus transmission is dependent on relative humidity and temperature.

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