Evaluation of topical erythropoietin application on the healing outcome of gingival graft recipient site; a randomized controlled clinical trial

Abstract Background Free gingival graft (FGG) is a highly predictable method to increase the width of keratinized gingiva. Various materials have been reported to accelerate the wound healing process. Considering the positive effect of EPO on dermal wound healing this study aimed to investigate the...

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Autores principales:	Siamak Yaghobee, Nina Rouzmeh, Mina Taheri, Hoori Aslroosta, Sanaz Mahmoodi, Masoomeh Mohammadnejad Hardoroodi, Pardis Soleimanzadeh Azar, Afshin Khorsand
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Erythropoietin Wound healing Gingiva Inflammation Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/94632528752d45488ed6389bb9214212
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spelling	oai:doaj.org-article:94632528752d45488ed6389bb92142122021-11-14T12:32:23ZEvaluation of topical erythropoietin application on the healing outcome of gingival graft recipient site; a randomized controlled clinical trial10.1186/s12903-021-01948-81472-6831https://doaj.org/article/94632528752d45488ed6389bb92142122021-11-01T00:00:00Zhttps://doi.org/10.1186/s12903-021-01948-8https://doaj.org/toc/1472-6831Abstract Background Free gingival graft (FGG) is a highly predictable method to increase the width of keratinized gingiva. Various materials have been reported to accelerate the wound healing process. Considering the positive effect of EPO on dermal wound healing this study aimed to investigate the effects of EPO on the rate of healing and degree of inflammation in free gingival grafts. Methods Seventeen patients with bilateral lack of keratinized gingiva in mandible were selected for this clinical trial. The surgical intervention was performed after phase I periodontal therapy. Recipient site was prepared apical to the mucogingival line, and FGG was harvested from the palate. Before graft placement, the test side and control side were treated with 1 ml of EPO 4000 IU/ml and distilled water, respectively, for 2 min. On days 7, 14, 21, 28, 60, and 90 after surgery, the grafted sites were examined by blinded observers to compare the healing and inflammation of the areas. Results All the 17 patients completed the surgeries and follow-up examinations. Direct examination revealed significantly better healing in EPO group only on the 28th day. Assessment of the photographs showed a significant value in favor of the test group at some other time points as well. The EPO group demonstrated less inflammation, which was statistically significant in many time points. The graft area was 80.88 ± 30.21 mm2 and 71.35 ± 15.62 mm2 in the EPO and control groups, respectively. The difference was not significant, though. Conclusions Topical application of erythropoietin can accelerate the healing of gingival grafts and reduce the inflammation during healing period. The final graft outcome, nevertheless, does not seem to be influenced by EPO. Trial registration This was a split-mouth randomized controlled clinical trial (IRCT201201278830N1). The first registration date: 2016-10-22Siamak YaghobeeNina RouzmehMina TaheriHoori AslroostaSanaz MahmoodiMasoomeh Mohammadnejad HardoroodiPardis Soleimanzadeh AzarAfshin KhorsandBMCarticleErythropoietinWound healingGingivaInflammationDentistryRK1-715ENBMC Oral Health, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Erythropoietin Wound healing Gingiva Inflammation Dentistry RK1-715
spellingShingle	Erythropoietin Wound healing Gingiva Inflammation Dentistry RK1-715 Siamak Yaghobee Nina Rouzmeh Mina Taheri Hoori Aslroosta Sanaz Mahmoodi Masoomeh Mohammadnejad Hardoroodi Pardis Soleimanzadeh Azar Afshin Khorsand Evaluation of topical erythropoietin application on the healing outcome of gingival graft recipient site; a randomized controlled clinical trial
description	Abstract Background Free gingival graft (FGG) is a highly predictable method to increase the width of keratinized gingiva. Various materials have been reported to accelerate the wound healing process. Considering the positive effect of EPO on dermal wound healing this study aimed to investigate the effects of EPO on the rate of healing and degree of inflammation in free gingival grafts. Methods Seventeen patients with bilateral lack of keratinized gingiva in mandible were selected for this clinical trial. The surgical intervention was performed after phase I periodontal therapy. Recipient site was prepared apical to the mucogingival line, and FGG was harvested from the palate. Before graft placement, the test side and control side were treated with 1 ml of EPO 4000 IU/ml and distilled water, respectively, for 2 min. On days 7, 14, 21, 28, 60, and 90 after surgery, the grafted sites were examined by blinded observers to compare the healing and inflammation of the areas. Results All the 17 patients completed the surgeries and follow-up examinations. Direct examination revealed significantly better healing in EPO group only on the 28th day. Assessment of the photographs showed a significant value in favor of the test group at some other time points as well. The EPO group demonstrated less inflammation, which was statistically significant in many time points. The graft area was 80.88 ± 30.21 mm2 and 71.35 ± 15.62 mm2 in the EPO and control groups, respectively. The difference was not significant, though. Conclusions Topical application of erythropoietin can accelerate the healing of gingival grafts and reduce the inflammation during healing period. The final graft outcome, nevertheless, does not seem to be influenced by EPO. Trial registration This was a split-mouth randomized controlled clinical trial (IRCT201201278830N1). The first registration date: 2016-10-22
format	article
author	Siamak Yaghobee Nina Rouzmeh Mina Taheri Hoori Aslroosta Sanaz Mahmoodi Masoomeh Mohammadnejad Hardoroodi Pardis Soleimanzadeh Azar Afshin Khorsand
author_facet	Siamak Yaghobee Nina Rouzmeh Mina Taheri Hoori Aslroosta Sanaz Mahmoodi Masoomeh Mohammadnejad Hardoroodi Pardis Soleimanzadeh Azar Afshin Khorsand
author_sort	Siamak Yaghobee
title	Evaluation of topical erythropoietin application on the healing outcome of gingival graft recipient site; a randomized controlled clinical trial
title_short	Evaluation of topical erythropoietin application on the healing outcome of gingival graft recipient site; a randomized controlled clinical trial
title_full	Evaluation of topical erythropoietin application on the healing outcome of gingival graft recipient site; a randomized controlled clinical trial
title_fullStr	Evaluation of topical erythropoietin application on the healing outcome of gingival graft recipient site; a randomized controlled clinical trial
title_full_unstemmed	Evaluation of topical erythropoietin application on the healing outcome of gingival graft recipient site; a randomized controlled clinical trial
title_sort	evaluation of topical erythropoietin application on the healing outcome of gingival graft recipient site; a randomized controlled clinical trial
publisher	BMC
publishDate	2021
url	https://doaj.org/article/94632528752d45488ed6389bb9214212
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Evaluation of topical erythropoietin application on the healing outcome of gingival graft recipient site; a randomized controlled clinical trial

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