The vaccination threshold for SARS-CoV-2 depends on the indoor setting and room ventilation

Abstract Background Effective vaccines are now available for SARS-CoV-2 in the 2nd year of the COVID-19 pandemic, but there remains significant uncertainty surrounding the necessary vaccination rate to safely lift occupancy controls in public buildings and return to pre-pandemic norms. The aim of th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. Mikszewski, L. Stabile, G. Buonanno, L. Morawska
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	SARS-CoV-2 Airborne transmission Ventilation Vaccination Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/946540fb94b24765badc3e860c09e212
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:946540fb94b24765badc3e860c09e212
record_format	dspace
spelling	oai:doaj.org-article:946540fb94b24765badc3e860c09e2122021-11-28T12:41:58ZThe vaccination threshold for SARS-CoV-2 depends on the indoor setting and room ventilation10.1186/s12879-021-06884-01471-2334https://doaj.org/article/946540fb94b24765badc3e860c09e2122021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06884-0https://doaj.org/toc/1471-2334Abstract Background Effective vaccines are now available for SARS-CoV-2 in the 2nd year of the COVID-19 pandemic, but there remains significant uncertainty surrounding the necessary vaccination rate to safely lift occupancy controls in public buildings and return to pre-pandemic norms. The aim of this paper is to estimate setting-specific vaccination thresholds for SARS-CoV-2 to prevent sustained community transmission using classical principles of airborne contagion modeling. We calculated the airborne infection risk in three settings, a classroom, prison cell block, and restaurant, at typical ventilation rates, and then the expected number of infections resulting from this risk at varying percentages of occupant immunity. Results We estimate the setting-specific immunity threshold for control of wild-type SARS-CoV-2 to range from a low of 40% for a mechanically ventilation classroom to a high of 85% for a naturally ventilated restaurant. Conclusions If vaccination rates are limited to a theoretical minimum of approximately two-thirds of the population, enhanced ventilation above minimum standards for acceptable air quality is needed to reduce the frequency and severity of SARS-CoV-2 superspreading events in high-risk indoor environments.A. MikszewskiL. StabileG. BuonannoL. MorawskaBMCarticleSARS-CoV-2Airborne transmissionVentilationVaccinationInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 Airborne transmission Ventilation Vaccination Infectious and parasitic diseases RC109-216
spellingShingle	SARS-CoV-2 Airborne transmission Ventilation Vaccination Infectious and parasitic diseases RC109-216 A. Mikszewski L. Stabile G. Buonanno L. Morawska The vaccination threshold for SARS-CoV-2 depends on the indoor setting and room ventilation
description	Abstract Background Effective vaccines are now available for SARS-CoV-2 in the 2nd year of the COVID-19 pandemic, but there remains significant uncertainty surrounding the necessary vaccination rate to safely lift occupancy controls in public buildings and return to pre-pandemic norms. The aim of this paper is to estimate setting-specific vaccination thresholds for SARS-CoV-2 to prevent sustained community transmission using classical principles of airborne contagion modeling. We calculated the airborne infection risk in three settings, a classroom, prison cell block, and restaurant, at typical ventilation rates, and then the expected number of infections resulting from this risk at varying percentages of occupant immunity. Results We estimate the setting-specific immunity threshold for control of wild-type SARS-CoV-2 to range from a low of 40% for a mechanically ventilation classroom to a high of 85% for a naturally ventilated restaurant. Conclusions If vaccination rates are limited to a theoretical minimum of approximately two-thirds of the population, enhanced ventilation above minimum standards for acceptable air quality is needed to reduce the frequency and severity of SARS-CoV-2 superspreading events in high-risk indoor environments.
format	article
author	A. Mikszewski L. Stabile G. Buonanno L. Morawska
author_facet	A. Mikszewski L. Stabile G. Buonanno L. Morawska
author_sort	A. Mikszewski
title	The vaccination threshold for SARS-CoV-2 depends on the indoor setting and room ventilation
title_short	The vaccination threshold for SARS-CoV-2 depends on the indoor setting and room ventilation
title_full	The vaccination threshold for SARS-CoV-2 depends on the indoor setting and room ventilation
title_fullStr	The vaccination threshold for SARS-CoV-2 depends on the indoor setting and room ventilation
title_full_unstemmed	The vaccination threshold for SARS-CoV-2 depends on the indoor setting and room ventilation
title_sort	vaccination threshold for sars-cov-2 depends on the indoor setting and room ventilation
publisher	BMC
publishDate	2021
url	https://doaj.org/article/946540fb94b24765badc3e860c09e212
work_keys_str_mv	AT amikszewski thevaccinationthresholdforsarscov2dependsontheindoorsettingandroomventilation AT lstabile thevaccinationthresholdforsarscov2dependsontheindoorsettingandroomventilation AT gbuonanno thevaccinationthresholdforsarscov2dependsontheindoorsettingandroomventilation AT lmorawska thevaccinationthresholdforsarscov2dependsontheindoorsettingandroomventilation AT amikszewski vaccinationthresholdforsarscov2dependsontheindoorsettingandroomventilation AT lstabile vaccinationthresholdforsarscov2dependsontheindoorsettingandroomventilation AT gbuonanno vaccinationthresholdforsarscov2dependsontheindoorsettingandroomventilation AT lmorawska vaccinationthresholdforsarscov2dependsontheindoorsettingandroomventilation
_version_	1718407846616367104

The vaccination threshold for SARS-CoV-2 depends on the indoor setting and room ventilation

Ejemplares similares