Telocytes are major constituents of the angiogenic apparatus

Abstract The current study investigated role of telocytes (TCs) in angiogenesis during embryonic development of quail using immunohistochemistry (IHC), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The angiogenic apparatus consisted of TCs, endothelial cells, and ma...

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Autor principal:	Soha A. Soliman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9466b738bf9e4d0da7bb86cf5936f0bf
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spelling	oai:doaj.org-article:9466b738bf9e4d0da7bb86cf5936f0bf2021-12-02T15:53:03ZTelocytes are major constituents of the angiogenic apparatus10.1038/s41598-021-85166-w2045-2322https://doaj.org/article/9466b738bf9e4d0da7bb86cf5936f0bf2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85166-whttps://doaj.org/toc/2045-2322Abstract The current study investigated role of telocytes (TCs) in angiogenesis during embryonic development of quail using immunohistochemistry (IHC), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The angiogenic apparatus consisted of TCs, endothelial cells, and macrophages. TCs were identified morphologically by their telopodes and podoms using TEM and SEM and immunohistochemically using CD34, and vascular endothelial growth factor (VEGF). TCs also expressed CD68. TCs formed a three-dimensional network and established direct contact with blood vessels, sprouting endothelial cells, and active macrophages, while exerting their effect through paracrine signaling. VEGF was also expressed by endothelial cells and macrophages. Matrix metalloproteinase–9 (MMP-9) was expressed by TCs, endothelial cells, and macrophages. In conclusion, the expression of VEGF by TCs, endothelial cells, and macrophages is required for the proliferation and migration of endothelial cells and vascular growth. The expression of MMP-9 by TCs, endothelial cells, and macrophages is essential for the degradation of extracellular matrix (ECM) components during neoangiogenesis. Macrophages may facilitate phagocytosis and elimination of the degraded ECM components.Soha A. SolimanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Soha A. Soliman Telocytes are major constituents of the angiogenic apparatus
description	Abstract The current study investigated role of telocytes (TCs) in angiogenesis during embryonic development of quail using immunohistochemistry (IHC), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The angiogenic apparatus consisted of TCs, endothelial cells, and macrophages. TCs were identified morphologically by their telopodes and podoms using TEM and SEM and immunohistochemically using CD34, and vascular endothelial growth factor (VEGF). TCs also expressed CD68. TCs formed a three-dimensional network and established direct contact with blood vessels, sprouting endothelial cells, and active macrophages, while exerting their effect through paracrine signaling. VEGF was also expressed by endothelial cells and macrophages. Matrix metalloproteinase–9 (MMP-9) was expressed by TCs, endothelial cells, and macrophages. In conclusion, the expression of VEGF by TCs, endothelial cells, and macrophages is required for the proliferation and migration of endothelial cells and vascular growth. The expression of MMP-9 by TCs, endothelial cells, and macrophages is essential for the degradation of extracellular matrix (ECM) components during neoangiogenesis. Macrophages may facilitate phagocytosis and elimination of the degraded ECM components.
format	article
author	Soha A. Soliman
author_facet	Soha A. Soliman
author_sort	Soha A. Soliman
title	Telocytes are major constituents of the angiogenic apparatus
title_short	Telocytes are major constituents of the angiogenic apparatus
title_full	Telocytes are major constituents of the angiogenic apparatus
title_fullStr	Telocytes are major constituents of the angiogenic apparatus
title_full_unstemmed	Telocytes are major constituents of the angiogenic apparatus
title_sort	telocytes are major constituents of the angiogenic apparatus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9466b738bf9e4d0da7bb86cf5936f0bf
work_keys_str_mv	AT sohaasoliman telocytesaremajorconstituentsoftheangiogenicapparatus
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Telocytes are major constituents of the angiogenic apparatus

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