Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity

Full-length VAR2CSA is a potential placental malaria vaccine candidate and in this study, Renn et al. compare antigenicity and receptor binding affinity of different allelic variants in blood samples from pregnant women. Their data show that inter-allelic differences may contribute to the heterogene...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jonathan P. Renn, Justin Y. A. Doritchamou, Bergeline C. Nguemwo Tentokam, Robert D. Morrison, Matthew V. Cowles, Martin Burkhardt, Rui Ma, Niraj H. Tolia, Michal Fried, Patrick E. Duffy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9468370d9ab9416c980d5d735228618e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9468370d9ab9416c980d5d735228618e
record_format	dspace
spelling	oai:doaj.org-article:9468370d9ab9416c980d5d735228618e2021-11-21T12:08:21ZAllelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity10.1038/s42003-021-02787-72399-3642https://doaj.org/article/9468370d9ab9416c980d5d735228618e2021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02787-7https://doaj.org/toc/2399-3642Full-length VAR2CSA is a potential placental malaria vaccine candidate and in this study, Renn et al. compare antigenicity and receptor binding affinity of different allelic variants in blood samples from pregnant women. Their data show that inter-allelic differences may contribute to the heterogeneity of clinical presentations, which could have implications for vaccine design.Jonathan P. RennJustin Y. A. DoritchamouBergeline C. Nguemwo TentokamRobert D. MorrisonMatthew V. CowlesMartin BurkhardtRui MaNiraj H. ToliaMichal FriedPatrick E. DuffyNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jonathan P. Renn Justin Y. A. Doritchamou Bergeline C. Nguemwo Tentokam Robert D. Morrison Matthew V. Cowles Martin Burkhardt Rui Ma Niraj H. Tolia Michal Fried Patrick E. Duffy Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity
description	Full-length VAR2CSA is a potential placental malaria vaccine candidate and in this study, Renn et al. compare antigenicity and receptor binding affinity of different allelic variants in blood samples from pregnant women. Their data show that inter-allelic differences may contribute to the heterogeneity of clinical presentations, which could have implications for vaccine design.
format	article
author	Jonathan P. Renn Justin Y. A. Doritchamou Bergeline C. Nguemwo Tentokam Robert D. Morrison Matthew V. Cowles Martin Burkhardt Rui Ma Niraj H. Tolia Michal Fried Patrick E. Duffy
author_facet	Jonathan P. Renn Justin Y. A. Doritchamou Bergeline C. Nguemwo Tentokam Robert D. Morrison Matthew V. Cowles Martin Burkhardt Rui Ma Niraj H. Tolia Michal Fried Patrick E. Duffy
author_sort	Jonathan P. Renn
title	Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity
title_short	Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity
title_full	Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity
title_fullStr	Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity
title_full_unstemmed	Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity
title_sort	allelic variants of full-length var2csa, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9468370d9ab9416c980d5d735228618e
work_keys_str_mv	AT jonathanprenn allelicvariantsoffulllengthvar2csatheplacentalmalariavaccinecandidatedifferinantigenicityandreceptorbindingaffinity AT justinyadoritchamou allelicvariantsoffulllengthvar2csatheplacentalmalariavaccinecandidatedifferinantigenicityandreceptorbindingaffinity AT bergelinecnguemwotentokam allelicvariantsoffulllengthvar2csatheplacentalmalariavaccinecandidatedifferinantigenicityandreceptorbindingaffinity AT robertdmorrison allelicvariantsoffulllengthvar2csatheplacentalmalariavaccinecandidatedifferinantigenicityandreceptorbindingaffinity AT matthewvcowles allelicvariantsoffulllengthvar2csatheplacentalmalariavaccinecandidatedifferinantigenicityandreceptorbindingaffinity AT martinburkhardt allelicvariantsoffulllengthvar2csatheplacentalmalariavaccinecandidatedifferinantigenicityandreceptorbindingaffinity AT ruima allelicvariantsoffulllengthvar2csatheplacentalmalariavaccinecandidatedifferinantigenicityandreceptorbindingaffinity AT nirajhtolia allelicvariantsoffulllengthvar2csatheplacentalmalariavaccinecandidatedifferinantigenicityandreceptorbindingaffinity AT michalfried allelicvariantsoffulllengthvar2csatheplacentalmalariavaccinecandidatedifferinantigenicityandreceptorbindingaffinity AT patrickeduffy allelicvariantsoffulllengthvar2csatheplacentalmalariavaccinecandidatedifferinantigenicityandreceptorbindingaffinity
_version_	1718419200065667072

Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity

Ejemplares similares