NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation

Germline mono-allelic loss of the tumour suppressor NF1 predisposes patients to the development of benign lesions but rarely further progression into cancer development. Here the authors use mouse models to show that an NF1 heterozygous microenvironment accelerates the formation of benign tumours bu...

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Autores principales:	Jean-Philippe Brosseau, Chung-Ping Liao, Yong Wang, Vijay Ramani, Travis Vandergriff, Michelle Lee, Amisha Patel, Kiyoshi Ariizumi, Lu Q. Le
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9469062130ae408ba5616d707d78a78d
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spelling	oai:doaj.org-article:9469062130ae408ba5616d707d78a78d2021-12-02T17:32:48ZNF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation10.1038/s41467-018-07452-y2041-1723https://doaj.org/article/9469062130ae408ba5616d707d78a78d2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07452-yhttps://doaj.org/toc/2041-1723Germline mono-allelic loss of the tumour suppressor NF1 predisposes patients to the development of benign lesions but rarely further progression into cancer development. Here the authors use mouse models to show that an NF1 heterozygous microenvironment accelerates the formation of benign tumours but impairs progression to malignancy.Jean-Philippe BrosseauChung-Ping LiaoYong WangVijay RamaniTravis VandergriffMichelle LeeAmisha PatelKiyoshi AriizumiLu Q. LeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jean-Philippe Brosseau Chung-Ping Liao Yong Wang Vijay Ramani Travis Vandergriff Michelle Lee Amisha Patel Kiyoshi Ariizumi Lu Q. Le NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation
description	Germline mono-allelic loss of the tumour suppressor NF1 predisposes patients to the development of benign lesions but rarely further progression into cancer development. Here the authors use mouse models to show that an NF1 heterozygous microenvironment accelerates the formation of benign tumours but impairs progression to malignancy.
format	article
author	Jean-Philippe Brosseau Chung-Ping Liao Yong Wang Vijay Ramani Travis Vandergriff Michelle Lee Amisha Patel Kiyoshi Ariizumi Lu Q. Le
author_facet	Jean-Philippe Brosseau Chung-Ping Liao Yong Wang Vijay Ramani Travis Vandergriff Michelle Lee Amisha Patel Kiyoshi Ariizumi Lu Q. Le
author_sort	Jean-Philippe Brosseau
title	NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation
title_short	NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation
title_full	NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation
title_fullStr	NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation
title_full_unstemmed	NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation
title_sort	nf1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9469062130ae408ba5616d707d78a78d
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NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation

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