Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis

Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis

Abstract Lamin B1, a key component of the nuclear lamina, plays an important role in brain development. Ablation of endogenous Lamin B1 (Lmnb1) in the mouse strongly impairs embryonic brain development and corticogenesis. However, the mechanisms underlying these neurodevelopmental effects are unknow...

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Autores principales: Sameehan Mahajani, Caterina Giacomini, Federica Marinaro, Davide De Pietri Tonelli, Andrea Contestabile, Laura Gasparini
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/946911ef6d464a83bd2e68edbd01b72d
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