MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes.
The myelination of axons is a crucial step during vertebrate central nervous system (CNS) development, allowing for rapid and energy efficient saltatory conduction of nerve impulses. Accordingly, the differentiation of oligodendrocytes, the myelinating cells of the CNS, and their expression of myeli...
Guardado en:
Autores principales: | Helena Bujalka, Matthias Koenning, Stacey Jackson, Victoria M Perreau, Bernard Pope, Curtis M Hay, Stanlislaw Mitew, Andrew F Hill, Q Richard Lu, Michael Wegner, Rajini Srinivasan, John Svaren, Melanie Willingham, Ben A Barres, Ben Emery |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2013
|
Materias: | |
Acceso en línea: | https://doaj.org/article/946c16919be64298bd55ab4d3e4a051d |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
The oligodendrocyte-enriched orphan G protein-coupled receptor Gpr62 is dispensable for central nervous system myelination
por: Curtis M. Hay, et al.
Publicado: (2021) -
A Bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF.
por: Zhihua Li, et al.
Publicado: (2013) -
Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
por: Stanislaw Mitew, et al.
Publicado: (2018) -
Design of modular autoproteolytic gene switches responsive to anti-coronavirus drug candidates
por: Nik Franko, et al.
Publicado: (2021) -
CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain.
por: Andrea D'Osualdo, et al.
Publicado: (2011)