The Impact of Mismatch Repair Status on Prognosis of Patients With Gastric Cancer: A Multicenter Analysis
BackgroundThe clinical role of deficient DNA mismatch repair (dMMR)/microsatellite instability-high (MSI-H) in gastric cancer (GC) is still controversial. We aimed to analyze the relationship between dMMR/MSI-H and clinicopathological features along with survival.MethodsPatients who were diagnosed w...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:947158bc848143c1915ded579ec7f0042021-11-30T23:14:05ZThe Impact of Mismatch Repair Status on Prognosis of Patients With Gastric Cancer: A Multicenter Analysis2234-943X10.3389/fonc.2021.712760https://doaj.org/article/947158bc848143c1915ded579ec7f0042021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.712760/fullhttps://doaj.org/toc/2234-943XBackgroundThe clinical role of deficient DNA mismatch repair (dMMR)/microsatellite instability-high (MSI-H) in gastric cancer (GC) is still controversial. We aimed to analyze the relationship between dMMR/MSI-H and clinicopathological features along with survival.MethodsPatients who were diagnosed with GC at the three big cancer centers in China from 2015 to 2020 were evaluated retrospectively. MMR/MSI status was assessed using immunohistochemistry/PCR. Clinical and pathological data were collected from the medical record system.ResultsA total of 196 patients with dMMR/MSI-H status were enrolled for analysis. The prevalence of MSI-H/dMMR in GC was 6.6%. Another 694 proficient MMR (pMMR) GC patients were enrolled for comparison. Compared with pMMR patients, dMMR/MSI-H patients were associated with older age, female predominance, distal location in the stomach, earlier TNM stage, intestinal subtype, better differentiation, and more negative HER2 status. The median overall survival (OS) of the dMMR/MSI-H group was better than that of the pMMR/microsatellite stability (MSS) group (not reached vs. 53.9 months, p = 0.014). Adjuvant chemotherapy had no impact in both disease-free survival (DFS) and OS of dMMR/MSI-H patients (p = 0.135 and 0.818, respectively). dMMR/MSI-H patients had poorer response and progression-free survival (PFS) of first-line chemotherapy, though they were statistically significant (p = 0.361 and 0.124, respectively).ConclusionsdMMR/MSI-H GC patients have specific clinicopathological characteristics and better prognosis than pMMR patients.Wen-Long GuanYue MaYue-Hong CuiTian-Shu LiuYan-Qiao ZhangZhi-Wei ZhouJian-Ying XuLi-Qiong YangJia-Yu LiYu-Ting SunRui-Hua XuFeng-Hua WangMiao-Zhen QiuFrontiers Media S.A.articleMMRMSIgastric canceradjuvant chemotherapyprognosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
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DOAJ |
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EN |
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MMR MSI gastric cancer adjuvant chemotherapy prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
MMR MSI gastric cancer adjuvant chemotherapy prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Wen-Long Guan Yue Ma Yue-Hong Cui Tian-Shu Liu Yan-Qiao Zhang Zhi-Wei Zhou Jian-Ying Xu Li-Qiong Yang Jia-Yu Li Yu-Ting Sun Rui-Hua Xu Feng-Hua Wang Miao-Zhen Qiu The Impact of Mismatch Repair Status on Prognosis of Patients With Gastric Cancer: A Multicenter Analysis |
| description |
BackgroundThe clinical role of deficient DNA mismatch repair (dMMR)/microsatellite instability-high (MSI-H) in gastric cancer (GC) is still controversial. We aimed to analyze the relationship between dMMR/MSI-H and clinicopathological features along with survival.MethodsPatients who were diagnosed with GC at the three big cancer centers in China from 2015 to 2020 were evaluated retrospectively. MMR/MSI status was assessed using immunohistochemistry/PCR. Clinical and pathological data were collected from the medical record system.ResultsA total of 196 patients with dMMR/MSI-H status were enrolled for analysis. The prevalence of MSI-H/dMMR in GC was 6.6%. Another 694 proficient MMR (pMMR) GC patients were enrolled for comparison. Compared with pMMR patients, dMMR/MSI-H patients were associated with older age, female predominance, distal location in the stomach, earlier TNM stage, intestinal subtype, better differentiation, and more negative HER2 status. The median overall survival (OS) of the dMMR/MSI-H group was better than that of the pMMR/microsatellite stability (MSS) group (not reached vs. 53.9 months, p = 0.014). Adjuvant chemotherapy had no impact in both disease-free survival (DFS) and OS of dMMR/MSI-H patients (p = 0.135 and 0.818, respectively). dMMR/MSI-H patients had poorer response and progression-free survival (PFS) of first-line chemotherapy, though they were statistically significant (p = 0.361 and 0.124, respectively).ConclusionsdMMR/MSI-H GC patients have specific clinicopathological characteristics and better prognosis than pMMR patients. |
| format |
article |
| author |
Wen-Long Guan Yue Ma Yue-Hong Cui Tian-Shu Liu Yan-Qiao Zhang Zhi-Wei Zhou Jian-Ying Xu Li-Qiong Yang Jia-Yu Li Yu-Ting Sun Rui-Hua Xu Feng-Hua Wang Miao-Zhen Qiu |
| author_facet |
Wen-Long Guan Yue Ma Yue-Hong Cui Tian-Shu Liu Yan-Qiao Zhang Zhi-Wei Zhou Jian-Ying Xu Li-Qiong Yang Jia-Yu Li Yu-Ting Sun Rui-Hua Xu Feng-Hua Wang Miao-Zhen Qiu |
| author_sort |
Wen-Long Guan |
| title |
The Impact of Mismatch Repair Status on Prognosis of Patients With Gastric Cancer: A Multicenter Analysis |
| title_short |
The Impact of Mismatch Repair Status on Prognosis of Patients With Gastric Cancer: A Multicenter Analysis |
| title_full |
The Impact of Mismatch Repair Status on Prognosis of Patients With Gastric Cancer: A Multicenter Analysis |
| title_fullStr |
The Impact of Mismatch Repair Status on Prognosis of Patients With Gastric Cancer: A Multicenter Analysis |
| title_full_unstemmed |
The Impact of Mismatch Repair Status on Prognosis of Patients With Gastric Cancer: A Multicenter Analysis |
| title_sort |
impact of mismatch repair status on prognosis of patients with gastric cancer: a multicenter analysis |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/947158bc848143c1915ded579ec7f004 |
| work_keys_str_mv |
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