High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients

Abstract Little is known of the patterns of expression of ACE2 and TMPRSS2 or the clinical characteristics of COVID-19 in patients with COVID-19 and colorectal cancer. We found in both bulk and single-cell RNA-seq profiles that ACE2 and TMPRSS2 were expressed at high levels on tumor and normal color...

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Autores principales:	Chao Liu, Kai Wang, Min Zhang, Xiaoyu Hu, Tian Hu, Yumei Liu, Qinyong Hu, Shikai Wu, Jinbo Yue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9472ab4f31ee4e34bbdaed2b77bf21e3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:9472ab4f31ee4e34bbdaed2b77bf21e32021-12-02T14:26:47ZHigh expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients10.1038/s41698-020-00139-y2397-768Xhttps://doaj.org/article/9472ab4f31ee4e34bbdaed2b77bf21e32021-01-01T00:00:00Zhttps://doi.org/10.1038/s41698-020-00139-yhttps://doaj.org/toc/2397-768XAbstract Little is known of the patterns of expression of ACE2 and TMPRSS2 or the clinical characteristics of COVID-19 in patients with COVID-19 and colorectal cancer. We found in both bulk and single-cell RNA-seq profiles that ACE2 and TMPRSS2 were expressed at high levels on tumor and normal colorectal epithelial tissues. Clinically, patients with colorectal cancer and COVID-19 were more likely to have lymphopenia, higher respiratory rate, and high hypersensitive C-reactive protein levels than matched patients with COVID-19 but without cancer. These results suggest that patients with colorectal cancer may be particularly susceptible to SARS-CoV-2 infection. Further mechanistic studies are needed to support our findings.Chao LiuKai WangMin ZhangXiaoyu HuTian HuYumei LiuQinyong HuShikai WuJinbo YueNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 5, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Chao Liu Kai Wang Min Zhang Xiaoyu Hu Tian Hu Yumei Liu Qinyong Hu Shikai Wu Jinbo Yue High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients
description	Abstract Little is known of the patterns of expression of ACE2 and TMPRSS2 or the clinical characteristics of COVID-19 in patients with COVID-19 and colorectal cancer. We found in both bulk and single-cell RNA-seq profiles that ACE2 and TMPRSS2 were expressed at high levels on tumor and normal colorectal epithelial tissues. Clinically, patients with colorectal cancer and COVID-19 were more likely to have lymphopenia, higher respiratory rate, and high hypersensitive C-reactive protein levels than matched patients with COVID-19 but without cancer. These results suggest that patients with colorectal cancer may be particularly susceptible to SARS-CoV-2 infection. Further mechanistic studies are needed to support our findings.
format	article
author	Chao Liu Kai Wang Min Zhang Xiaoyu Hu Tian Hu Yumei Liu Qinyong Hu Shikai Wu Jinbo Yue
author_facet	Chao Liu Kai Wang Min Zhang Xiaoyu Hu Tian Hu Yumei Liu Qinyong Hu Shikai Wu Jinbo Yue
author_sort	Chao Liu
title	High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients
title_short	High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients
title_full	High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients
title_fullStr	High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients
title_full_unstemmed	High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients
title_sort	high expression of ace2 and tmprss2 and clinical characteristics of covid-19 in colorectal cancer patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9472ab4f31ee4e34bbdaed2b77bf21e3
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High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients

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