Surgical Treatment of Postoperative Abdominal Metastases of Hepatocellular Carcinoma: 10-Year Experience in a Single Center
Jiong-Ze Fang,* Yong Yang,* Hong-Da Zhu, Jian-Nan Sun, Hong-Chao Mi, Cai-De Lu Department of Hepatopancreatobiliary Surgery, Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang, People’s Republic of China*These authors contributed equally to this workC...
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Dove Medical Press
2021
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oai:doaj.org-article:9474a0f10de14d29a1d96dac6ba5cce62021-11-21T19:08:51ZSurgical Treatment of Postoperative Abdominal Metastases of Hepatocellular Carcinoma: 10-Year Experience in a Single Center1179-1322https://doaj.org/article/9474a0f10de14d29a1d96dac6ba5cce62021-11-01T00:00:00Zhttps://www.dovepress.com/surgical-treatment-of-postoperative-abdominal-metastases-of-hepatocell-peer-reviewed-fulltext-article-CMARhttps://doaj.org/toc/1179-1322Jiong-Ze Fang,* Yong Yang,* Hong-Da Zhu, Jian-Nan Sun, Hong-Chao Mi, Cai-De Lu Department of Hepatopancreatobiliary Surgery, Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Cai-De Lu Tel/Fax +86 574- 55835600Email lucaide@nbu.edu.cnObjective: The significance of surgical treatment was analyzed by retrospectively collecting data on the re-resection of intra-abdominal metastases after hepatocellular carcinoma (HCC) surgery in our center over the past 10 years.Methods: The clinical and pathological data of 15 patients who developed intra-abdominal metastases after HCC resection and underwent re-resection from January 2010 to January 2020 were collected to analyze the patients’ characteristics and prognosis.Results: Of the 15 cases of abdominal metastasis, the majority (8 cases) had greater omental metastasis. There were 4 cases of mesenteric metastases, 1 case of abdominal wall metastasis, 1 case of mesenteric plus rectal wall metastasis, and 1 case of colon and mesenteric metastasis. The 1-year, 3-year, and 5-year disease-free survival (DFS) rates were 31.1%, 23.3%, and 11.7%, respectively. The 1-year, 3-year, and 5-year overall survival rates were 93.3%, 28.7%, and 19.1%, respectively. Three patients are currently surviving disease-free, with survival times of 130.4 months, 43.3 months, and 9.4 months, respectively.Conclusion: Although the current guidelines do not recommend surgical resection as the preferred treatment for postoperative abdominal metastases of HCC, surgical resection is recommended for patients with limited or solitary metastasis in the abdominal cavity.Keywords: hepatocellular carcinoma, postoperative recurrence of HCC, intra-abdominal metastasis, disease-free survival, overall survivalFang JYang YZhu HDSun JNMi HCLu CDDove Medical Pressarticlehepatocellular carcinomapostoperative recurrence of hccintra-abdominal metastasisdisease-free survivaloverall survivalNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Management and Research, Vol Volume 13, Pp 8673-8683 (2021) |
| institution |
DOAJ |
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DOAJ |
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EN |
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hepatocellular carcinoma postoperative recurrence of hcc intra-abdominal metastasis disease-free survival overall survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
hepatocellular carcinoma postoperative recurrence of hcc intra-abdominal metastasis disease-free survival overall survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Fang J Yang Y Zhu HD Sun JN Mi HC Lu CD Surgical Treatment of Postoperative Abdominal Metastases of Hepatocellular Carcinoma: 10-Year Experience in a Single Center |
| description |
Jiong-Ze Fang,* Yong Yang,* Hong-Da Zhu, Jian-Nan Sun, Hong-Chao Mi, Cai-De Lu Department of Hepatopancreatobiliary Surgery, Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Cai-De Lu Tel/Fax +86 574- 55835600Email lucaide@nbu.edu.cnObjective: The significance of surgical treatment was analyzed by retrospectively collecting data on the re-resection of intra-abdominal metastases after hepatocellular carcinoma (HCC) surgery in our center over the past 10 years.Methods: The clinical and pathological data of 15 patients who developed intra-abdominal metastases after HCC resection and underwent re-resection from January 2010 to January 2020 were collected to analyze the patients’ characteristics and prognosis.Results: Of the 15 cases of abdominal metastasis, the majority (8 cases) had greater omental metastasis. There were 4 cases of mesenteric metastases, 1 case of abdominal wall metastasis, 1 case of mesenteric plus rectal wall metastasis, and 1 case of colon and mesenteric metastasis. The 1-year, 3-year, and 5-year disease-free survival (DFS) rates were 31.1%, 23.3%, and 11.7%, respectively. The 1-year, 3-year, and 5-year overall survival rates were 93.3%, 28.7%, and 19.1%, respectively. Three patients are currently surviving disease-free, with survival times of 130.4 months, 43.3 months, and 9.4 months, respectively.Conclusion: Although the current guidelines do not recommend surgical resection as the preferred treatment for postoperative abdominal metastases of HCC, surgical resection is recommended for patients with limited or solitary metastasis in the abdominal cavity.Keywords: hepatocellular carcinoma, postoperative recurrence of HCC, intra-abdominal metastasis, disease-free survival, overall survival |
| format |
article |
| author |
Fang J Yang Y Zhu HD Sun JN Mi HC Lu CD |
| author_facet |
Fang J Yang Y Zhu HD Sun JN Mi HC Lu CD |
| author_sort |
Fang J |
| title |
Surgical Treatment of Postoperative Abdominal Metastases of Hepatocellular Carcinoma: 10-Year Experience in a Single Center |
| title_short |
Surgical Treatment of Postoperative Abdominal Metastases of Hepatocellular Carcinoma: 10-Year Experience in a Single Center |
| title_full |
Surgical Treatment of Postoperative Abdominal Metastases of Hepatocellular Carcinoma: 10-Year Experience in a Single Center |
| title_fullStr |
Surgical Treatment of Postoperative Abdominal Metastases of Hepatocellular Carcinoma: 10-Year Experience in a Single Center |
| title_full_unstemmed |
Surgical Treatment of Postoperative Abdominal Metastases of Hepatocellular Carcinoma: 10-Year Experience in a Single Center |
| title_sort |
surgical treatment of postoperative abdominal metastases of hepatocellular carcinoma: 10-year experience in a single center |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/9474a0f10de14d29a1d96dac6ba5cce6 |
| work_keys_str_mv |
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