Photoplethysmography for the Assessment of Haemorheology

Abstract Haemorheology has been long identified as an early biomarker of a wide range of diseases, especially cardiovascular diseases. This study investigates for the first time the suitability of Photoplethysmography (PPG) as a non-invasive diagnostic method for haemorheological changes. The sensit...

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Autores principales:	Haneen Njoum, Panayiotis A. Kyriacou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/94753c0eb78443d6abc4bcb86ca92403
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spelling	oai:doaj.org-article:94753c0eb78443d6abc4bcb86ca924032021-12-02T15:05:51ZPhotoplethysmography for the Assessment of Haemorheology10.1038/s41598-017-01636-02045-2322https://doaj.org/article/94753c0eb78443d6abc4bcb86ca924032017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01636-0https://doaj.org/toc/2045-2322Abstract Haemorheology has been long identified as an early biomarker of a wide range of diseases, especially cardiovascular diseases. This study investigates for the first time the suitability of Photoplethysmography (PPG) as a non-invasive diagnostic method for haemorheological changes. The sensitivity of both PPG components (AC and DC) to changes in haemorheology were rigorously investigated in an in vitro experimental setup that mimics the human circulation. A custom-made reflectance PPG sensor, a pressure transducer and an ultrasonic Doppler flowmeter were used to map changes in flow dynamics and optical responses in an arterial model. The study investigated the effect of shear rates by varying fluid pumping frequencies using 4 set-points and the effect of clot formation using a chemical trigger. Both PPGAC amplitudes and PPGDC levels showed significant (p < 0.001) changes during the increase in shear rates and an immediate change after thromboplastin activation. The findings highlight that PPG has the potential to be used as a simple non-invasive method for the detection of blood characteristics, including disaggregation, radial migration and cross-linking fibrin formations. Such capability will enable the assessment of the effects of clotting-activators and anticoagulants (including non-pharmacological methods) and might aid in the early non-invasive assessment of cardiovascular pathologies.Haneen NjoumPanayiotis A. KyriacouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haneen Njoum Panayiotis A. Kyriacou Photoplethysmography for the Assessment of Haemorheology
description	Abstract Haemorheology has been long identified as an early biomarker of a wide range of diseases, especially cardiovascular diseases. This study investigates for the first time the suitability of Photoplethysmography (PPG) as a non-invasive diagnostic method for haemorheological changes. The sensitivity of both PPG components (AC and DC) to changes in haemorheology were rigorously investigated in an in vitro experimental setup that mimics the human circulation. A custom-made reflectance PPG sensor, a pressure transducer and an ultrasonic Doppler flowmeter were used to map changes in flow dynamics and optical responses in an arterial model. The study investigated the effect of shear rates by varying fluid pumping frequencies using 4 set-points and the effect of clot formation using a chemical trigger. Both PPGAC amplitudes and PPGDC levels showed significant (p < 0.001) changes during the increase in shear rates and an immediate change after thromboplastin activation. The findings highlight that PPG has the potential to be used as a simple non-invasive method for the detection of blood characteristics, including disaggregation, radial migration and cross-linking fibrin formations. Such capability will enable the assessment of the effects of clotting-activators and anticoagulants (including non-pharmacological methods) and might aid in the early non-invasive assessment of cardiovascular pathologies.
format	article
author	Haneen Njoum Panayiotis A. Kyriacou
author_facet	Haneen Njoum Panayiotis A. Kyriacou
author_sort	Haneen Njoum
title	Photoplethysmography for the Assessment of Haemorheology
title_short	Photoplethysmography for the Assessment of Haemorheology
title_full	Photoplethysmography for the Assessment of Haemorheology
title_fullStr	Photoplethysmography for the Assessment of Haemorheology
title_full_unstemmed	Photoplethysmography for the Assessment of Haemorheology
title_sort	photoplethysmography for the assessment of haemorheology
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/94753c0eb78443d6abc4bcb86ca92403
work_keys_str_mv	AT haneennjoum photoplethysmographyfortheassessmentofhaemorheology AT panayiotisakyriacou photoplethysmographyfortheassessmentofhaemorheology
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Photoplethysmography for the Assessment of Haemorheology

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