Highly sensitive determination of α-lipoic acid in pharmaceuticals on a boron-doped diamond electrode

A simple, highly sensitive, and selective differential pulse voltammetry method for the determination of α-lipoic acid (LA) in pharmaceutical preparations was developed and validated. The method is based on a quasi-reversible, diffusion-controlled, one-electron anodic oxidation of LA on a boron-dope...

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Autores principales:	Skorupa Agata, Michalkiewicz Slawomir, Jakubczyk Magdalena
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	α-la oxidation determination bdde aqueous buffers Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/9477a08d2366475699fa121df8f000fa
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spelling	oai:doaj.org-article:9477a08d2366475699fa121df8f000fa2021-12-05T14:10:44ZHighly sensitive determination of α-lipoic acid in pharmaceuticals on a boron-doped diamond electrode2391-542010.1515/chem-2021-0075https://doaj.org/article/9477a08d2366475699fa121df8f000fa2021-08-01T00:00:00Zhttps://doi.org/10.1515/chem-2021-0075https://doaj.org/toc/2391-5420A simple, highly sensitive, and selective differential pulse voltammetry method for the determination of α-lipoic acid (LA) in pharmaceutical preparations was developed and validated. The method is based on a quasi-reversible, diffusion-controlled, one-electron anodic oxidation of LA on a boron-doped diamond electrode (BDDE) in a McIlvaine (citrate-phosphate, C-PB) buffer solution at pH 3.0. For the first time, this environment was used for LA determination. A linear calibration curve was obtained within the concentration range 5.82 × 10−8 to 4.00 × 10−4 mol L−1 with a correlation coefficient of 0.9999. The limits of detection was estimated to be 1.94 × 10−8 mol L−1, which is one of the lowest values characteristic of voltammetric and chromatographic methods of LA determination. The proposed procedure is sensitive, accurate, and precise. Its utility was demonstrated in the determination of LA in pharmaceuticals without the need for its separation from the matrices. The results were comparable to those obtained by high performance liquid chromatography reference method and were in good accordance with the once declared by manufacturers. Thus, our method can be considered as an alternative to the dominant chromatographic determinations of α-LA in real samples.Skorupa AgataMichalkiewicz SlawomirJakubczyk MagdalenaDe Gruyterarticleα-laoxidationdeterminationbddeaqueous buffersChemistryQD1-999ENOpen Chemistry, Vol 19, Iss 1, Pp 843-854 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	α-la oxidation determination bdde aqueous buffers Chemistry QD1-999
spellingShingle	α-la oxidation determination bdde aqueous buffers Chemistry QD1-999 Skorupa Agata Michalkiewicz Slawomir Jakubczyk Magdalena Highly sensitive determination of α-lipoic acid in pharmaceuticals on a boron-doped diamond electrode
description	A simple, highly sensitive, and selective differential pulse voltammetry method for the determination of α-lipoic acid (LA) in pharmaceutical preparations was developed and validated. The method is based on a quasi-reversible, diffusion-controlled, one-electron anodic oxidation of LA on a boron-doped diamond electrode (BDDE) in a McIlvaine (citrate-phosphate, C-PB) buffer solution at pH 3.0. For the first time, this environment was used for LA determination. A linear calibration curve was obtained within the concentration range 5.82 × 10−8 to 4.00 × 10−4 mol L−1 with a correlation coefficient of 0.9999. The limits of detection was estimated to be 1.94 × 10−8 mol L−1, which is one of the lowest values characteristic of voltammetric and chromatographic methods of LA determination. The proposed procedure is sensitive, accurate, and precise. Its utility was demonstrated in the determination of LA in pharmaceuticals without the need for its separation from the matrices. The results were comparable to those obtained by high performance liquid chromatography reference method and were in good accordance with the once declared by manufacturers. Thus, our method can be considered as an alternative to the dominant chromatographic determinations of α-LA in real samples.
format	article
author	Skorupa Agata Michalkiewicz Slawomir Jakubczyk Magdalena
author_facet	Skorupa Agata Michalkiewicz Slawomir Jakubczyk Magdalena
author_sort	Skorupa Agata
title	Highly sensitive determination of α-lipoic acid in pharmaceuticals on a boron-doped diamond electrode
title_short	Highly sensitive determination of α-lipoic acid in pharmaceuticals on a boron-doped diamond electrode
title_full	Highly sensitive determination of α-lipoic acid in pharmaceuticals on a boron-doped diamond electrode
title_fullStr	Highly sensitive determination of α-lipoic acid in pharmaceuticals on a boron-doped diamond electrode
title_full_unstemmed	Highly sensitive determination of α-lipoic acid in pharmaceuticals on a boron-doped diamond electrode
title_sort	highly sensitive determination of α-lipoic acid in pharmaceuticals on a boron-doped diamond electrode
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/9477a08d2366475699fa121df8f000fa
work_keys_str_mv	AT skorupaagata highlysensitivedeterminationofalipoicacidinpharmaceuticalsonaborondopeddiamondelectrode AT michalkiewiczslawomir highlysensitivedeterminationofalipoicacidinpharmaceuticalsonaborondopeddiamondelectrode AT jakubczykmagdalena highlysensitivedeterminationofalipoicacidinpharmaceuticalsonaborondopeddiamondelectrode
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Highly sensitive determination of α-lipoic acid in pharmaceuticals on a boron-doped diamond electrode

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