MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery

Abstract Persistent organic pollutants (POPs) are synthetic chemical substances that accumulate in our environment. POPs such as polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB) and dichlorodiphenyltrichloroethane (DDT) have been classified as carcinogenic to humans and animals. Due to thei...

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Autores principales:	Julian Krauskopf, Theo M. de Kok, Dennie G. Hebels, Ingvar A. Bergdahl, Anders Johansson, Florentin Spaeth, Hannu Kiviranta, Panu Rantakokko, Soterios A. Kyrtopoulos, Jos C. Kleinjans
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/947a90425e8b4fa5a288db68f2cb2660
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spelling	oai:doaj.org-article:947a90425e8b4fa5a288db68f2cb26602021-12-02T16:07:46ZMicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery10.1038/s41598-017-10167-72045-2322https://doaj.org/article/947a90425e8b4fa5a288db68f2cb26602017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-10167-7https://doaj.org/toc/2045-2322Abstract Persistent organic pollutants (POPs) are synthetic chemical substances that accumulate in our environment. POPs such as polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB) and dichlorodiphenyltrichloroethane (DDT) have been classified as carcinogenic to humans and animals. Due to their resistance to biodegradation humans are still exposed to these compounds worldwide. We aim to evaluate the miRNA and transcriptomic response of a human population exposed to POPs. The miRNA and transcriptomic response was measured in blood of healthy subjects by microarray technology and associated with the serum concentrations of six PCB congeners, DDE (a common DDT metabolite), and HCB. A total of 93 miRNA levels appeared significantly associated with the POP-exposure (FDR < 0.05). The miRNA profile includes four tumor suppressor miRNAs, namely miR-193a-3p, miR-152, miR-31-5p and miR-34a-5p. Integration of the miRNA profile with the transcriptome profile suggests an interaction with oncogenes such as MYC, CCND1, BCL2 and VEGFA. We have shown that exposure to POPs is associated with human miRNA and transcriptomic responses. The identified miRNAs and target genes are related to various types of cancer and involved in relevant signaling pathways like wnt and p53. Therefore, these miRNAs may have great potential to contribute to biomarker-based environmental health risk assessment.Julian KrauskopfTheo M. de KokDennie G. HebelsIngvar A. BergdahlAnders JohanssonFlorentin SpaethHannu KivirantaPanu RantakokkoSoterios A. KyrtopoulosJos C. KleinjansNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julian Krauskopf Theo M. de Kok Dennie G. Hebels Ingvar A. Bergdahl Anders Johansson Florentin Spaeth Hannu Kiviranta Panu Rantakokko Soterios A. Kyrtopoulos Jos C. Kleinjans MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery
description	Abstract Persistent organic pollutants (POPs) are synthetic chemical substances that accumulate in our environment. POPs such as polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB) and dichlorodiphenyltrichloroethane (DDT) have been classified as carcinogenic to humans and animals. Due to their resistance to biodegradation humans are still exposed to these compounds worldwide. We aim to evaluate the miRNA and transcriptomic response of a human population exposed to POPs. The miRNA and transcriptomic response was measured in blood of healthy subjects by microarray technology and associated with the serum concentrations of six PCB congeners, DDE (a common DDT metabolite), and HCB. A total of 93 miRNA levels appeared significantly associated with the POP-exposure (FDR < 0.05). The miRNA profile includes four tumor suppressor miRNAs, namely miR-193a-3p, miR-152, miR-31-5p and miR-34a-5p. Integration of the miRNA profile with the transcriptome profile suggests an interaction with oncogenes such as MYC, CCND1, BCL2 and VEGFA. We have shown that exposure to POPs is associated with human miRNA and transcriptomic responses. The identified miRNAs and target genes are related to various types of cancer and involved in relevant signaling pathways like wnt and p53. Therefore, these miRNAs may have great potential to contribute to biomarker-based environmental health risk assessment.
format	article
author	Julian Krauskopf Theo M. de Kok Dennie G. Hebels Ingvar A. Bergdahl Anders Johansson Florentin Spaeth Hannu Kiviranta Panu Rantakokko Soterios A. Kyrtopoulos Jos C. Kleinjans
author_facet	Julian Krauskopf Theo M. de Kok Dennie G. Hebels Ingvar A. Bergdahl Anders Johansson Florentin Spaeth Hannu Kiviranta Panu Rantakokko Soterios A. Kyrtopoulos Jos C. Kleinjans
author_sort	Julian Krauskopf
title	MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery
title_short	MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery
title_full	MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery
title_fullStr	MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery
title_full_unstemmed	MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery
title_sort	microrna profile for health risk assessment: environmental exposure to persistent organic pollutants strongly affects the human blood microrna machinery
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/947a90425e8b4fa5a288db68f2cb2660
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MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery

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