RSPO4-CRISPR alleviates liver injury and restores gut microbiota in a rat model of liver fibrosis

Yu et al. demonstrates the role of RSPO4, a Wnt signaling agonist, in liver fibrogenesis and its impact on the gut microbiome. By knocking out RSPO4 gene in fibrotic-liver rat model, they show that it relieved liver fibrosis in rats and restored the microflora composition, highlighting its potential...

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Autores principales:	Linghua Yu, Linlin Wang, Xiaojun Wu, Huixing Yi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/947c323cd3b446e695a7975e2c4376da
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spelling	oai:doaj.org-article:947c323cd3b446e695a7975e2c4376da2021-12-02T14:21:58ZRSPO4-CRISPR alleviates liver injury and restores gut microbiota in a rat model of liver fibrosis10.1038/s42003-021-01747-52399-3642https://doaj.org/article/947c323cd3b446e695a7975e2c4376da2021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01747-5https://doaj.org/toc/2399-3642Yu et al. demonstrates the role of RSPO4, a Wnt signaling agonist, in liver fibrogenesis and its impact on the gut microbiome. By knocking out RSPO4 gene in fibrotic-liver rat model, they show that it relieved liver fibrosis in rats and restored the microflora composition, highlighting its potential in liver fibrosis treatment.Linghua YuLinlin WangXiaojun WuHuixing YiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Linghua Yu Linlin Wang Xiaojun Wu Huixing Yi RSPO4-CRISPR alleviates liver injury and restores gut microbiota in a rat model of liver fibrosis
description	Yu et al. demonstrates the role of RSPO4, a Wnt signaling agonist, in liver fibrogenesis and its impact on the gut microbiome. By knocking out RSPO4 gene in fibrotic-liver rat model, they show that it relieved liver fibrosis in rats and restored the microflora composition, highlighting its potential in liver fibrosis treatment.
format	article
author	Linghua Yu Linlin Wang Xiaojun Wu Huixing Yi
author_facet	Linghua Yu Linlin Wang Xiaojun Wu Huixing Yi
author_sort	Linghua Yu
title	RSPO4-CRISPR alleviates liver injury and restores gut microbiota in a rat model of liver fibrosis
title_short	RSPO4-CRISPR alleviates liver injury and restores gut microbiota in a rat model of liver fibrosis
title_full	RSPO4-CRISPR alleviates liver injury and restores gut microbiota in a rat model of liver fibrosis
title_fullStr	RSPO4-CRISPR alleviates liver injury and restores gut microbiota in a rat model of liver fibrosis
title_full_unstemmed	RSPO4-CRISPR alleviates liver injury and restores gut microbiota in a rat model of liver fibrosis
title_sort	rspo4-crispr alleviates liver injury and restores gut microbiota in a rat model of liver fibrosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/947c323cd3b446e695a7975e2c4376da
work_keys_str_mv	AT linghuayu rspo4crispralleviatesliverinjuryandrestoresgutmicrobiotainaratmodelofliverfibrosis AT linlinwang rspo4crispralleviatesliverinjuryandrestoresgutmicrobiotainaratmodelofliverfibrosis AT xiaojunwu rspo4crispralleviatesliverinjuryandrestoresgutmicrobiotainaratmodelofliverfibrosis AT huixingyi rspo4crispralleviatesliverinjuryandrestoresgutmicrobiotainaratmodelofliverfibrosis
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RSPO4-CRISPR alleviates liver injury and restores gut microbiota in a rat model of liver fibrosis

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