Anticancer efficacy enhancement and attenuation of side effects of doxorubicin with titanium dioxide nanoparticles

Yan Chen1,*, Ying Wan1,*, Yi Wang1, Haijun Zhang2, Zhijun Jiao11Key Laboratory of Medical Immunology and Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang; 2Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, People&r...

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Autores principales:	Chen Y, Wan Y, Wang Y, Zhang H, Jiao Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/947fa82be16a4e3b844057fda05a2bd6
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spelling	oai:doaj.org-article:947fa82be16a4e3b844057fda05a2bd62021-12-02T02:30:51ZAnticancer efficacy enhancement and attenuation of side effects of doxorubicin with titanium dioxide nanoparticles1176-91141178-2013https://doaj.org/article/947fa82be16a4e3b844057fda05a2bd62011-10-01T00:00:00Zhttp://www.dovepress.com/anticancer-efficacy-enhancement-and-attenuation-of-side-effects-of-dox-a8485https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Yan Chen1,, Ying Wan1,, Yi Wang1, Haijun Zhang2, Zhijun Jiao11Key Laboratory of Medical Immunology and Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang; 2Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, People&rsquo;s Republic of China *These authors have contributed equally to this workBackground: Doxorubicin has a broad spectrum of anticancer activity, but its clinical application is limited due to serious side effects. The aim of this study was to explore a novel drug delivery system based on titanium dioxide (TiO2) nanoparticles for its potential role in enhancing the anticancer efficacy of doxorubicin while reducing its side effects.Methods and results: Doxorubicin was loaded into TiO2 nanoparticles by forming complexes with the transition metal, titanium, to construct doxorubicin-titanium dioxide (DOX-TiO2) nanocomposites as a drug delivery system. The anticancer activity of the DOX-TiO2 nanocomposites was demonstrated by MTT assay, and the possible signaling pathway was explored by Western blot. In human SMMC-7721 hepatocarcinoma cells, our observations demonstrated that this drug delivery system markedly increased the efficiency of drug per dosage and decreased the IC50, resulting in anticancer efficacy enhancement and side effect attenuation.Conclusion: Such a doxorubicin delivery strategy is promising in cancer therapy. Apoptosis may contribute to the mechanism, due to protein expression of Bcl-2 being downregulated and that of Bax and caspase 3 being upregulated.Keywords: doxorubicin, titanium dioxide nanoparticles, drug delivery system, apoptosisChen YWan YWang YZhang HJiao ZDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 2321-2326 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Chen Y Wan Y Wang Y Zhang H Jiao Z Anticancer efficacy enhancement and attenuation of side effects of doxorubicin with titanium dioxide nanoparticles
description	Yan Chen1,, Ying Wan1,, Yi Wang1, Haijun Zhang2, Zhijun Jiao11Key Laboratory of Medical Immunology and Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang; 2Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, People&rsquo;s Republic of China *These authors have contributed equally to this workBackground: Doxorubicin has a broad spectrum of anticancer activity, but its clinical application is limited due to serious side effects. The aim of this study was to explore a novel drug delivery system based on titanium dioxide (TiO2) nanoparticles for its potential role in enhancing the anticancer efficacy of doxorubicin while reducing its side effects.Methods and results: Doxorubicin was loaded into TiO2 nanoparticles by forming complexes with the transition metal, titanium, to construct doxorubicin-titanium dioxide (DOX-TiO2) nanocomposites as a drug delivery system. The anticancer activity of the DOX-TiO2 nanocomposites was demonstrated by MTT assay, and the possible signaling pathway was explored by Western blot. In human SMMC-7721 hepatocarcinoma cells, our observations demonstrated that this drug delivery system markedly increased the efficiency of drug per dosage and decreased the IC50, resulting in anticancer efficacy enhancement and side effect attenuation.Conclusion: Such a doxorubicin delivery strategy is promising in cancer therapy. Apoptosis may contribute to the mechanism, due to protein expression of Bcl-2 being downregulated and that of Bax and caspase 3 being upregulated.Keywords: doxorubicin, titanium dioxide nanoparticles, drug delivery system, apoptosis
format	article
author	Chen Y Wan Y Wang Y Zhang H Jiao Z
author_facet	Chen Y Wan Y Wang Y Zhang H Jiao Z
author_sort	Chen Y
title	Anticancer efficacy enhancement and attenuation of side effects of doxorubicin with titanium dioxide nanoparticles
title_short	Anticancer efficacy enhancement and attenuation of side effects of doxorubicin with titanium dioxide nanoparticles
title_full	Anticancer efficacy enhancement and attenuation of side effects of doxorubicin with titanium dioxide nanoparticles
title_fullStr	Anticancer efficacy enhancement and attenuation of side effects of doxorubicin with titanium dioxide nanoparticles
title_full_unstemmed	Anticancer efficacy enhancement and attenuation of side effects of doxorubicin with titanium dioxide nanoparticles
title_sort	anticancer efficacy enhancement and attenuation of side effects of doxorubicin with titanium dioxide nanoparticles
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/947fa82be16a4e3b844057fda05a2bd6
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Anticancer efficacy enhancement and attenuation of side effects of doxorubicin with titanium dioxide nanoparticles

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