Urinary Metabolic Markers of Bladder Cancer: A Reflection of the Tumor or the Response of the Body?

This work will review the metabolic information that various studies have obtained in recent years on bladder cancer, with particular attention to discovering biomarkers in urine for the diagnosis and prognosis of this disease. In principle, they would be capable of complementing cystoscopy, an inva...

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Autores principales:	Greta Petrella, Giorgia Ciufolini, Riccardo Vago, Daniel Oscar Cicero
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bladder cancer metabolomics diagnostic prognostic systemic response Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/9482d9264b9e479fb44d1ebc78b9b2b9
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spelling	oai:doaj.org-article:9482d9264b9e479fb44d1ebc78b9b2b92021-11-25T18:20:41ZUrinary Metabolic Markers of Bladder Cancer: A Reflection of the Tumor or the Response of the Body?10.3390/metabo111107562218-1989https://doaj.org/article/9482d9264b9e479fb44d1ebc78b9b2b92021-10-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/756https://doaj.org/toc/2218-1989This work will review the metabolic information that various studies have obtained in recent years on bladder cancer, with particular attention to discovering biomarkers in urine for the diagnosis and prognosis of this disease. In principle, they would be capable of complementing cystoscopy, an invasive but nowadays irreplaceable technique or, in the best case, of replacing it. We will evaluate the degree of reproducibility that the different experiments have shown in the indication of biomarkers, and a synthesis will be attempted to obtain a consensus list that is more likely to become a guideline for clinical practice. In further analysis, we will inquire into the origin of these dysregulated metabolites in patients with bladder cancer. For this purpose, it will be helpful to compare the imbalances measured in urine with those known inside tumor cells or tissues. Although the urine analysis is sometimes considered a liquid biopsy because of its direct contact with the tumor in the bladder wall, it contains metabolites from all organs and tissues of the body, and the tumor is separated from urine by the most impermeable barrier found in mammals. The distinction between the specific and systemic responses can help understand the disease and its consequences in more depth.Greta PetrellaGiorgia CiufoliniRiccardo VagoDaniel Oscar CiceroMDPI AGarticlebladder cancermetabolomicsdiagnosticprognosticsystemic responseMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 756, p 756 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bladder cancer metabolomics diagnostic prognostic systemic response Microbiology QR1-502
spellingShingle	bladder cancer metabolomics diagnostic prognostic systemic response Microbiology QR1-502 Greta Petrella Giorgia Ciufolini Riccardo Vago Daniel Oscar Cicero Urinary Metabolic Markers of Bladder Cancer: A Reflection of the Tumor or the Response of the Body?
description	This work will review the metabolic information that various studies have obtained in recent years on bladder cancer, with particular attention to discovering biomarkers in urine for the diagnosis and prognosis of this disease. In principle, they would be capable of complementing cystoscopy, an invasive but nowadays irreplaceable technique or, in the best case, of replacing it. We will evaluate the degree of reproducibility that the different experiments have shown in the indication of biomarkers, and a synthesis will be attempted to obtain a consensus list that is more likely to become a guideline for clinical practice. In further analysis, we will inquire into the origin of these dysregulated metabolites in patients with bladder cancer. For this purpose, it will be helpful to compare the imbalances measured in urine with those known inside tumor cells or tissues. Although the urine analysis is sometimes considered a liquid biopsy because of its direct contact with the tumor in the bladder wall, it contains metabolites from all organs and tissues of the body, and the tumor is separated from urine by the most impermeable barrier found in mammals. The distinction between the specific and systemic responses can help understand the disease and its consequences in more depth.
format	article
author	Greta Petrella Giorgia Ciufolini Riccardo Vago Daniel Oscar Cicero
author_facet	Greta Petrella Giorgia Ciufolini Riccardo Vago Daniel Oscar Cicero
author_sort	Greta Petrella
title	Urinary Metabolic Markers of Bladder Cancer: A Reflection of the Tumor or the Response of the Body?
title_short	Urinary Metabolic Markers of Bladder Cancer: A Reflection of the Tumor or the Response of the Body?
title_full	Urinary Metabolic Markers of Bladder Cancer: A Reflection of the Tumor or the Response of the Body?
title_fullStr	Urinary Metabolic Markers of Bladder Cancer: A Reflection of the Tumor or the Response of the Body?
title_full_unstemmed	Urinary Metabolic Markers of Bladder Cancer: A Reflection of the Tumor or the Response of the Body?
title_sort	urinary metabolic markers of bladder cancer: a reflection of the tumor or the response of the body?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9482d9264b9e479fb44d1ebc78b9b2b9
work_keys_str_mv	AT gretapetrella urinarymetabolicmarkersofbladdercancerareflectionofthetumorortheresponseofthebody AT giorgiaciufolini urinarymetabolicmarkersofbladdercancerareflectionofthetumorortheresponseofthebody AT riccardovago urinarymetabolicmarkersofbladdercancerareflectionofthetumorortheresponseofthebody AT danieloscarcicero urinarymetabolicmarkersofbladdercancerareflectionofthetumorortheresponseofthebody
_version_	1718411332849500160

Urinary Metabolic Markers of Bladder Cancer: A Reflection of the Tumor or the Response of the Body?

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