Maraviroc, a CCR5 antagonist, prevents development of hepatocellular carcinoma in a mouse model.

Chronic liver disease may result in a sequential progression through fibrosis, cirrhosis and lead, eventually, to hepatocellular carcinoma (HCC). Hepatic stellate cells (HSC) seem to be responsible for the fibrogenic response through the activation of an autocrine loop involving the chemokine recept...

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Autores principales: Laura Ochoa-Callejero, Laura Pérez-Martínez, Susana Rubio-Mediavilla, José A Oteo, Alfredo Martínez, José R Blanco
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/9483bbcf38d94b9ca0c397d5de1c2366
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