A dynamic allosteric pathway underlies Rad50 ABC ATPase function in DNA repair

A dynamic allosteric pathway underlies Rad50 ABC ATPase function in DNA repair

Abstract The Mre11-Rad50 protein complex is an initial responder to sites of DNA double strand breaks. Many studies have shown that ATP binding to Rad50 causes global changes to the Mre11-Rad50 structure, which are important for DNA repair functions. Here we used methyl-based NMR spectroscopy on a s...

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Autores principales: Zachary K. Boswell, Samiur Rahman, Marella D. Canny, Michael P. Latham
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/9483ddab1c2f42be85f632a0db182db5
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