Administration of ghrelin associated with decreased expression of matrix metalloproteinase-9 following normobaric systemic hypoxia in the brain

Objective. According to our previous studies, ghrelin protects blood brain barrier (BBB) integrity and it attenuates hypoxia-induced brain edema in the hypoxic conditions. However, the underlying mechanisms remain poorly understood. Several studies suggest a role for matrix metal-loproteinase-9 (MMP...

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Autores principales:	Mohaddes Gisou, Babri Shirin, Hossienzadeh Fezzeh
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2018
Materias:	hypoxic brain matrix metalloproteinase-9 ghrelin Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/94851c332f93405ca05e8356c706a2cc
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spelling	oai:doaj.org-article:94851c332f93405ca05e8356c706a2cc2021-12-02T16:41:13ZAdministration of ghrelin associated with decreased expression of matrix metalloproteinase-9 following normobaric systemic hypoxia in the brain1336-032910.2478/enr-2018-0019https://doaj.org/article/94851c332f93405ca05e8356c706a2cc2018-07-01T00:00:00Zhttps://doi.org/10.2478/enr-2018-0019https://doaj.org/toc/1336-0329Objective. According to our previous studies, ghrelin protects blood brain barrier (BBB) integrity and it attenuates hypoxia-induced brain edema in the hypoxic conditions. However, the underlying mechanisms remain poorly understood. Several studies suggest a role for matrix metal-loproteinase-9 (MMP9) in the BBB disruption and cerebral edema formation. The present study was conducted to determine the effect of ghrelin on MMP9 protein expression in the model of acute and chronic systemic hypoxia.Mohaddes GisouBabri ShirinHossienzadeh FezzehSciendoarticlehypoxic brainmatrix metalloproteinase-9ghrelinDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 52, Iss 3, Pp 152-158 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypoxic brain matrix metalloproteinase-9 ghrelin Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	hypoxic brain matrix metalloproteinase-9 ghrelin Diseases of the endocrine glands. Clinical endocrinology RC648-665 Mohaddes Gisou Babri Shirin Hossienzadeh Fezzeh Administration of ghrelin associated with decreased expression of matrix metalloproteinase-9 following normobaric systemic hypoxia in the brain
description	Objective. According to our previous studies, ghrelin protects blood brain barrier (BBB) integrity and it attenuates hypoxia-induced brain edema in the hypoxic conditions. However, the underlying mechanisms remain poorly understood. Several studies suggest a role for matrix metal-loproteinase-9 (MMP9) in the BBB disruption and cerebral edema formation. The present study was conducted to determine the effect of ghrelin on MMP9 protein expression in the model of acute and chronic systemic hypoxia.
format	article
author	Mohaddes Gisou Babri Shirin Hossienzadeh Fezzeh
author_facet	Mohaddes Gisou Babri Shirin Hossienzadeh Fezzeh
author_sort	Mohaddes Gisou
title	Administration of ghrelin associated with decreased expression of matrix metalloproteinase-9 following normobaric systemic hypoxia in the brain
title_short	Administration of ghrelin associated with decreased expression of matrix metalloproteinase-9 following normobaric systemic hypoxia in the brain
title_full	Administration of ghrelin associated with decreased expression of matrix metalloproteinase-9 following normobaric systemic hypoxia in the brain
title_fullStr	Administration of ghrelin associated with decreased expression of matrix metalloproteinase-9 following normobaric systemic hypoxia in the brain
title_full_unstemmed	Administration of ghrelin associated with decreased expression of matrix metalloproteinase-9 following normobaric systemic hypoxia in the brain
title_sort	administration of ghrelin associated with decreased expression of matrix metalloproteinase-9 following normobaric systemic hypoxia in the brain
publisher	Sciendo
publishDate	2018
url	https://doaj.org/article/94851c332f93405ca05e8356c706a2cc
work_keys_str_mv	AT mohaddesgisou administrationofghrelinassociatedwithdecreasedexpressionofmatrixmetalloproteinase9followingnormobaricsystemichypoxiainthebrain AT babrishirin administrationofghrelinassociatedwithdecreasedexpressionofmatrixmetalloproteinase9followingnormobaricsystemichypoxiainthebrain AT hossienzadehfezzeh administrationofghrelinassociatedwithdecreasedexpressionofmatrixmetalloproteinase9followingnormobaricsystemichypoxiainthebrain
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Administration of ghrelin associated with decreased expression of matrix metalloproteinase-9 following normobaric systemic hypoxia in the brain

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